(New page: {{BioPsy}} '''DOPAC''' ('''dihydroxyphenylacetic acid''') is a metabolite of dopamine. The dopaminergic pathway consists of the following: <pre> ----> via MAO -> '''...) |
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| − | ----> via MAO -> '''DOPAC''' -> via COMT |
+ | ----> via [[MAO]] -> '''DOPAC''' -> via [[COMT]] |
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/ \ |
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| − | '''Dopamine (DA)''' . . . . . . . . . . . . . . . . . . . |
+ | '''[[Dopamine]] (DA)''' . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ---> '''[[homovanillic acid]] (HVA)''' |
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\ / |
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| − | ----> via COMT -> '''3-MT''' -> via MAO |
+ | ----> via COMT -> '''[[3-MT]]''' -> via MAO |
</pre> |
</pre> |
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Revision as of 19:34, 11 February 2008
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DOPAC (dihydroxyphenylacetic acid) is a metabolite of dopamine. The dopaminergic pathway consists of the following:
----> via [[MAO]] -> '''DOPAC''' -> via [[COMT]]
/ \
'''[[Dopamine]] (DA)''' . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ---> '''[[homovanillic acid]] (HVA)'''
\ /
----> via COMT -> '''[[3-MT]]''' -> via MAO
One of the three direct products from the alteration of dopamine (DOPAC, 3-MT (3-methoxytyramine) and noradrenaline) DOPAC is an important metabolite when studying the behaviour of the dopaminergic system for multiple reasons; 3-MT is generally more difficult to assay alongside dopamine and by assessing all three metabolites (DOPAC, HVA and 3-MT) abnormalities in either COMT (catechol-O-methyl transferase) or MAO (monoamine oxidase) can be indirectly identified. This has large ramifications as COMT abnormalities are suspected in various neuropsychiatric diseases including schizophrenia.