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Diazoxide is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. This switches off voltage-gated calcium ion channels which inhibits the generation of an action potential.

It is used as a vasodilator in the treatment of acute hypertension, and also to decrease the secretion of insulin in disease states such as insulinoma (a tumor producing insulin).

Diazoxide is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. This switches off voltage-gated calcium ion channels which inhibits the generation of an action potential.

It is used as a vasodilator in the treatment of acute hypertension, and also to decrease the secretion of insulin in disease states such as insulinoma (a tumor producing insulin).

ReferencessEdit

• Avshalumov, M. V., Chen, B. T., Koos, T., Tepper, J. M., & Rice, M. E. (2005). Endogenous Hydrogen Peroxide Regulates the Excitability of Midbrain Dopamine Neurons via ATP-Sensitive Potassium Channels: Journal of Neuroscience Vol 25(17) Apr 2005, 4222-4231.
• Chi, X. X., Jiang, X., & Nicol, G. D. (2007). ATP-sensitive potassium currents reduce the PGE-sub-2-mediated enhancement of excitability in adult rat sensory neurons: Brain Research Vol 1145 May 2007, 28-40.
• Cockhill, L. A., & Remick, R. A. (1987). Blood pressure effects of monoamine oxidase inhibitors: The highs and lows: The Canadian Journal of Psychiatry / La Revue canadienne de psychiatrie Vol 32(9) Dec 1987, 803-808.
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• Hensley, I. E. (2000). Effects of diazoxide on NPY content in discrete brain nuclei of lean and obese zucker rats. Dissertation Abstracts International: Section B: The Sciences and Engineering.
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• Yang, Y., Liu, X., Long, Y., Wang, F., Ding, J.-H., Liu, S.-Y., et al. (2006). Activation of mitochondrial ATP-sensitive potassium channels improves rotenone-related motor and neurochemical alterations in rats: International Journal of Neuropsychopharmacology Vol 9(1) Feb 2006, 51-61.
• Zarrindast, M. R., Jafari, M. R., Shafaghi, B., & Djahanguiri, B. (2004). Influence of potassium channel modulators on morphine state-dependent memory of passive avoidance: Behavioural Pharmacology Vol 15(2) Mar 2004, 103-110.

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