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| − | '''Desipramine''' is a [[tricyclic antidepressant]] (TCA) that inhibits the reuptake of [[norepinephrine]]. It is sold under the brand names '''Norpramin''' |
+ | '''Desipramine''' is a [[tricyclic antidepressant]] (TCA) that inhibits the reuptake of [[norepinephrine]]. It is sold under the brand names '''Norpramin''' and '''Pertofrane'''. It is used to treat [[clinical depression|depression]], but not considered a first line treatment since the introduction of [[SSRI]] [[antidepressants]]. Desipramine is an active [[metabolite]] of [[imipramine]]. |
Along with other tricyclics, desipramine has found use in treating [[neuropathic pain]]. The mechanism of |
Along with other tricyclics, desipramine has found use in treating [[neuropathic pain]]. The mechanism of |
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| − | action seems to involve the activation, through norepinephrine reuptake inhibition, of descending pathways in the spinal |
+ | action seems to involve the activation, through norepinephrine reuptake inhibition, of descending pathways in the [[spinal cord]] that block pain signals from ascending to the [[brain]]. Desipramine is one of the most potent and selective |
| + | medications in this respect. It may also be used to treat symptoms of [[Attention Deficit Disorder]], as the underproduction of norepinephrine has been increasingly linked to symptoms associated with Attention Deficit Disorder. |
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| − | cord that block pain signals from ascending to the brain. Desipramine is one of the most potent and selective |
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| + | |||
| − | medications in this respect. |
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| + | == Genotoxity == |
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| + | |||
| + | Desipramin has been shown to be [[genotoxic]] in fruit flies and associated with an increased risk of breast cancer in women.<ref>British Journal of Cancer 2002: volume 86, pages 92-97</ref> |
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| + | |||
| + | |||
==See also== |
==See also== |
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| − | * [[ |
+ | * [[Antidepressant]] |
| + | |||
| − | * [[tricyclic antidepressant]] |
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==External links== |
==External links== |
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{{Antidepressants}} |
{{Antidepressants}} |
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| − | [[Category:Tricyclic |
+ | [[Category:Tricyclic antidepressant drugs]] |
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Latest revision as of 04:10, 14 November 2010
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Desipramine chemical structure | |
| 10, 11-dihydro-5-[3-(methylamino) propyl]-5H-dibenz[b,f]azepine monohydrochloride IUPAC name | |
| CAS number 50-47-5 |
ATC code |
| PubChem 2995 |
DrugBank APRD00022 |
| Chemical formula | {{{chemical_formula}}} |
| Molecular weight | 266.381 |
| Bioavailability | 73-92% |
| Metabolism | Hepatic |
| Elimination half-life | 21-23 hours |
| Excretion | Renal |
| Pregnancy category | |
| Legal status | Rx only |
| Routes of administration | oral |
Desipramine is a tricyclic antidepressant (TCA) that inhibits the reuptake of norepinephrine. It is sold under the brand names Norpramin and Pertofrane. It is used to treat depression, but not considered a first line treatment since the introduction of SSRI antidepressants. Desipramine is an active metabolite of imipramine.
Along with other tricyclics, desipramine has found use in treating neuropathic pain. The mechanism of action seems to involve the activation, through norepinephrine reuptake inhibition, of descending pathways in the spinal cord that block pain signals from ascending to the brain. Desipramine is one of the most potent and selective medications in this respect. It may also be used to treat symptoms of Attention Deficit Disorder, as the underproduction of norepinephrine has been increasingly linked to symptoms associated with Attention Deficit Disorder.
Genotoxity
Desipramin has been shown to be genotoxic in fruit flies and associated with an increased risk of breast cancer in women.[1]
See also
External links
- Desipramine - medicinenet.com
- Desipramine - medlineplus.org
| This page uses Creative Commons Licensed content from Wikipedia (view authors). |
- ↑ British Journal of Cancer 2002: volume 86, pages 92-97