Desipramine

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File:Desipramine.png Desipramine
10, 11-dihydro-5-[3-(methylamino) propyl]-5H-dibenz[b,f]azepine monohydrochloride IUPAC name
CAS number 50-47-5	ATC code N06AA01
PubChem 2995	DrugBank APRD00022
Chemical formula	{{{chemical_formula}}}
Molecular weight	266.381
Bioavailability	73-92%
Metabolism	Hepatic
Elimination half-life	21-23 hours
Excretion	Renal
Pregnancy category
Legal status	Rx only
Routes of administration	oral

Desipramine is a tricyclic antidepressant (TCA) that inhibits the reuptake of norepinephrine. It is sold under the brand names Norpramin and Pertofrane. It is used to treat depression, but not considered a first line treatment since the introduction of SSRI antidepressants. Desipramine is an active metabolite of imipramine.

Along with other tricyclics, desipramine has found use in treating neuropathic pain. The mechanism of action seems to involve the activation, through norepinephrine reuptake inhibition, of descending pathways in the spinal cord that block pain signals from ascending to the brain. Desipramine is one of the most potent and selective medications in this respect. It may also be used to treat symptoms of Attention Deficit Disorder, as the underproduction of norepinephrine has been increasingly linked to symptoms associated with Attention Deficit Disorder.

[edit] Genotoxity

Desipramin has been shown to be genotoxic in fruit flies and associated with an increased risk of breast cancer in women.^[1]

[edit] See also

• Antidepressant

[edit] External links

• Desipramine - medicinenet.com
• Desipramine - medlineplus.org

Antidepressants (ATC N06A) edit
Monoamine oxidase inhibitors (MAOI)	Harmaline, Iproclozide, Iproniazid, Isocarboxazid, Nialamide, Phenelzine, Selegiline, Toloxatone, Tranylcypromine
Reversible inhibitor of monoamine oxidase A (RIMA)	Brofaromine, Moclobemide
Dopamine reuptake inhibitor (DARI)	Amineptine, Phenmetrazine, Vanoxerine, Modafinil
Norepinephrine-dopamine reuptake inhibitors	Bupropion
Norepinephrine reuptake inhibitor (NRI) or (NARI)	Atomoxetine, Maprotiline, Reboxetine, Viloxazine
Serotonin-norepinephrine reuptake inhibitor (SNRI)	Duloxetine, Milnacipran, Venlafaxine
Selective serotonin reuptake inhibitor (SSRI)	Alaproclate, Etoperidone, Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Zimelidine
Selective serotonin reuptake enhancer (SSRE)	Tianeptine
Tricyclic antidepressants (TCA)	Amitriptyline, Amoxapine, Butriptyline, Clomipramine, Desipramine, Dibenzepin, Dothiepin, Doxepin, Imipramine, Iprindole, Lofepramine, Melitracen, Nortriptyline, Opipramol, Protriptyline, Trimipramine
Tetracyclic antidepressants	Maprotiline, Mianserin, Nefazodone, Trazodone
Noradrenergic and specific serotonergic antidepressant (NaSSA) Mirtazapine

This page uses content from the English-language version of Wikipedia. The original article was at Desipramine. The list of authors can be seen in the page history. As with Psychology Wiki, the text of Wikipedia is available under the GNU Free Documentation License.

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