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- Main article: Clinical depression
The Ebers papyrus (ca 1550 BC) contains a short description of clinical depression. Though full of incantations and foul applications meant to turn away disease-causing demons and other superstition, it also evinces a long tradition of empirical practice and observation.
Clinical depression was originally considered to be a chemical imbalance in transmitters in the brain, a theory based on observations made in the 1950s of the effects of reserpine and isoniazid in altering monoamine neurotransmitter levels and affecting depressive symptoms . Since these suggestions, many other causes for clinical depression have been proposed.
References & Bibliography
- ↑ Schildkraut, J.J. (1965). The catecholamine hypothesis of affective disorders: a review of supporting evidence. Am J Psychiatry 122 (5): 509-22.
Zilboorg G, Henry G W. (1941) A history of medical psychology. New York: W. W. Norton and Company,
- Berrios GE. Melancholia and depression during the 19th century: a conceptual History. British Journal of Psychiatry 1998 Sep, 153: 298-304.