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Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
Dehydroepiandosterone sulphate | |
---|---|
Dehydroepiandosterone sulphate | |
General | |
Systematic name | ? |
Other names | ? |
Molecular formula | ? |
SMILES | ? |
Molar mass | ?.?? g/mol |
Appearance | ? |
CAS number | [?-?-?] |
Properties | |
Density and phase | ? g/cm³, ? |
Solubility in water | ? g/100 ml (?°C) |
Melting point | ?°C (? K) |
Boiling point | ?°C (? K) |
Acidity (pKa) | ? |
Basicity (pKb) | ? |
Chiral rotation [α]D | ?° |
Viscosity | ? cP at ?°C |
Structure | |
Molecular shape | ? |
Coordination geometry |
? |
Crystal structure | ? |
Dipole moment | ? D |
Hazards | |
MSDS | External MSDS |
Main hazards | ? |
NFPA 704 | |
Flash point | ?°C |
R/S statement | R: ? S: ? |
RTECS number | ? |
Supplementary data page | |
Structure and properties |
n, εr, etc. |
Thermodynamic data |
Phase behaviour Solid, liquid, gas |
Spectral data | UV, IR, NMR, MS |
Related compounds | |
Other anions | ? |
Other cations | ? |
Related ? | ? |
Related compounds | ? |
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
Dehydroepiandrosterone sulfate or DHEA sulfate is a metabolite of dehydroepiandrosterone (DHEA).
Synthesis[]
Dehydroepiandrosterone sulfate is produced by the addition of a sulfate group, catalyzed by the sulfotransferase enzymes SULT1A1 and SULT1E1, which also produce estrone sulfate from estrone. DHEA sulfate can also be back-converted to DHEA through the action of steroid sulfatase.
In the zona reticularis layer of the adrenal cortex, DHEA-sulfate is generated by SULT2A1.[1] This layer of the adrenal cortex is thought to be the primary source of serum DHEA-sulfate. DHEA sulfate levels decline as a person ages as the reticularis layer diminishes in size.
Use as biomarker[]
Dehydroepiandrosterone sulfate levels above 1890 micromol/L or 700-800 µg/dL are highly suggestive of adrenal dysfunction because DHEA-S is made exclusively by the adrenal glands.[2][3]
Reference ranges[]
Tanner stage and average age | Lower limit | Upper limit | Unit | |
---|---|---|---|---|
Tanner stage I | >14 days | 16 | 96 | µg/dL |
Tanner stage II | 10.5 years | 22 | 184 | |
Tanner stage III | 11.6 years | <15 | 296 | |
Tanner stage IV | 12.3 years | 17 | 343 | |
Tanner stage V | 14.5 years | 44 | 332 | |
18-29 years | 44 | 332 | ||
30-39 years | 31 | 228 | ||
40-49 years | 18 | 244 | ||
50-59 years | <15 | 200 | ||
> or =60 years | <15 | 157 |
Tanner stage and average age | Lower limit | Upper limit | Unit | |
---|---|---|---|---|
Tanner stage I | >14 days | <15 | 120 | µg/dL |
Tanner stage II | 11.5 years | <15 | 333 | |
Tanner stage III | 13.6 years | <15 | 312 | |
Tanner stage IV | 15.1 years | 29 | 412 | |
Tanner stage V | 18.0 years | 89 | 457 | |
18-29 years | 89 | 457 | ||
30-39 years | 65 | 334 | ||
40-49 years | 48 | 244 | ||
50-59 years | 35 | 179 | ||
> or =60 years | 25 | 131 |
See also[]
References[]
- ↑ Rainey WE, Nakamura Y (February 2008). Regulation of the adrenal androgen biosynthesis. J. Steroid Biochem. Mol. Biol. 108 (3-5): 281–6.
- ↑ Somani N, Harrison S, Bergfeld WF (2008). The clinical evaluation of hirsutism. Dermatologic therapy 21 (5): 376–91.
- ↑ Polycystic Ovarian Syndrome Workup. eMedicine. URL accessed on 19 November 2011.
- ↑ 4.0 4.1 Dehydroepiandrosterone Sulfate (DHEA-S), Serum at Mayo Foundation For Medical Education And Research. Retrieved July 2012
Template:Steroid hormones Template:Glucocorticoids
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