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|style="background: #F8EABA; text-align: center;" colspan="2"||Dimethylethanolamine|
|style="background: #F8EABA; text-align: center;" colspan="2"|| Except where noted otherwise, data are given for|
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references
Dimethylaminoethanol, also known as DMAE or dimethylethanolamine, is an organic compound. This compound also goes by the names of N,N-dimethyl-2-aminoethanol, beta-dimethylaminoethyl alcohol, beta-hydroxyethyldimethylamine and Deanol. It is a liquid with a color that ranges from clear to pale yellow.
Dimethylaminoethanol is used as a curing agent for polyurethanes and epoxy resins. It is used to the synthesis of dyestuffs, textile auxiliaries, pharmaceuticals, emulsifiers, and corrosion inhibitors. Also it is an additive to paint removers, boiler water, and amino resins.
Dimethylaminoethanol is related to choline and is a biochemical precursor to the neurotransmitter acetylcholine, and found naturally in fishes like sardines and anchovies. It is reported to have nootropic effects, although research on this chemical has found both positive and negative potential results.
It is believed that dimethylaminoethanol is methylated to produce choline in the brain. It is known that dimethylaminoethanol is processed by the liver into choline; however, the choline molecule is charged and cannot pass the blood-brain barrier.
Short term studies show an increase in vigilance and alertness, with a positive influence on mood. Long term studies are equivocal. Some showed dimethylaminoethanol to increase the lifespan of animals in which it was tested, while others indicate a possible reduction in the average life span of quail. With the uncertainty of whether this could be extrapolated to humans, dimethylaminoethanol supplementation is not generally recommended. It is possible that dose is a major determining factor in the overall effects of dimethylaminoethanol - a high dose could produce the opposite effects than sought and contribute to life-shortening.
- Earliest research
- As a treatment for tardive dyskinesia
- As an unsuccessful treatment for Alzheimer's disease
- Precursor to choline
- Zahniser NR, Chou D, Hanin I. Is 2-dimethylaminoethanol (deanol) indeed a precursor of brain acetylcholine? A gas chromatographic evaluation. Journal of Pharmacology and Experimental Therapeutics 200(3):545–559, 1977. 
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