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Dehydroepiandosterone sulphate

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Dehydroepiandosterone sulphate
Dehydroepiandosterone sulphate
General
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Infobox disclaimer and references


Dehydroepiandrosterone sulfate or DHEA sulfate is a metabolite of dehydroepiandrosterone (DHEA).

SynthesisEdit

Dehydroepiandrosterone sulfate is produced by the addition of a sulfate group, catalyzed by the sulfotransferase enzymes SULT1A1 and SULT1E1, which also produce estrone sulfate from estrone. DHEA sulfate can also be back-converted to DHEA through the action of steroid sulfatase.

In the zona reticularis layer of the adrenal cortex, DHEA-sulfate is generated by SULT2A1.[1] This layer of the adrenal cortex is thought to be the primary source of serum DHEA-sulfate. DHEA sulfate levels decline as a person ages as the reticularis layer diminishes in size.

Use as biomarkerEdit

Dehydroepiandrosterone sulfate levels above 1890 micromol/L or 700-800 µg/dL are highly suggestive of adrenal dysfunction because DHEA-S is made exclusively by the adrenal glands.[2][3]

Reference rangesEdit

Reference ranges for dehydroepiandrosterone sulfate in females[4]
Tanner stage and average age Lower limit Upper limit Unit
Tanner stage I >14 days 16 96 µg/dL
Tanner stage II 10.5 years 22 184
Tanner stage III 11.6 years <15 296
Tanner stage IV 12.3 years 17 343
Tanner stage V 14.5 years 44 332
18-29 years 44 332
30-39 years 31 228
40-49 years 18 244
50-59 years <15 200
> or =60 years <15 157
Reference ranges for dehydroepiandrosterone sulfate in males[4]
Tanner stage and average age Lower limit Upper limit Unit
Tanner stage I >14 days <15 120 µg/dL
Tanner stage II 11.5 years <15 333
Tanner stage III 13.6 years <15 312
Tanner stage IV 15.1 years 29 412
Tanner stage V 18.0 years 89 457
18-29 years 89 457
30-39 years 65 334
40-49 years 48 244
50-59 years 35 179
> or =60 years 25 131

See also Edit

References Edit

  1. Rainey WE, Nakamura Y (February 2008). Regulation of the adrenal androgen biosynthesis. J. Steroid Biochem. Mol. Biol. 108 (3-5): 281–6.
  2. Somani N, Harrison S, Bergfeld WF (2008). The clinical evaluation of hirsutism. Dermatologic therapy 21 (5): 376–91.
  3. Polycystic Ovarian Syndrome Workup. eMedicine. URL accessed on 19 November 2011.
  4. 4.0 4.1 Dehydroepiandrosterone Sulfate (DHEA-S), Serum at Mayo Foundation For Medical Education And Research. Retrieved July 2012

Template:Steroid hormones Template:Glucocorticoids

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