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Cyclic AMP receptors

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Cyclic AMP receptors from slim molds are a distinct family of G-protein coupled receptors. These receptors control development in Dictyostelium discoideum.

The cyclic AMP receptors coordinate aggregation of individual cells into a multicellular organism, and regulate the expression of a large number of developmentally-regulated genes[1][2][3]. The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains, in a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However, while a similar 3D framework has been proposed to account for this, there is no significant sequence similarity between these families: the cAMP receptors thus bear their own unique '7TM' signature.

ReferencesEdit

  1. Devreotes PN, Kimmel AR, Johnson RL, Klein PS, Sun TJ, Saxe III CL (1988). A chemoattractant receptor controls development in Dictyostelium discoideum. Science 241 (4872): 1467-1472.
  2. Ginsburg GT, Louis JM, Johnson R, Devreotes PN, Kimmel AR, Saxe III CL (1993). CAR2, a prestalk cAMP receptor required for normal tip formation and late development of Dictyostelium discoideum. Genes Dev. 7 (2): 262-272.
  3. Devreotes PN, Kimmel AR, Johnson RL, Gollop R, Saxe III CL (1993). Identification and targeted gene disruption of cAR3, a cAMP receptor subtype expressed during multicellular stages of Dictyostelium development. Genes Dev. 7 (2): 273-282.
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