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Conotoxin

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Ziconotide 1DW5

Schematic diagram of the three-dimensional structure of ω-conotoxin MVIIA (ziconotide). Disulfide bonds are shown in gold.

A conotoxin is one of a group of neurotoxic peptides isolated from the venom of the marine cone snail.

Conotoxins, which are peptides consisting of 10 to 30 amino acid residues, typically have some disulfide bonds. Conotoxins have a variety of activities, most of which have not been explained closely yet.

The number of conotoxins whose activities have been determined so far is five, and they are called the α(alpha)-, δ(delta)-, κ(kappa)-, μ(mu)-, and ω- types. Each of the five types of conotoxins attacks a different target:

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