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Connectograms are graphical representations of connectomics, the field of study dedicated to mapping and interpreting all of the white matter fiber connections in the human brain. These circular graphs can demonstrate the white matter connections and cortical characteristics for single structures, single subjects, or populations.

File:Connectogram Key.jpg

StructureEdit

File:ParcellationBrains.jpg

Connectograms are circular, with the left half depicting the left hemisphere and the right half depicting the right hemisphere. The hemispheres are further broken down into frontal lobe, insular cortex, limbic lobe, temporal lobe, parietal lobe, occipital lobe, subcortical structures, and cerebellum. At the bottom the brain stem is also represented between the two hemispheres. Within these lobes, each cortical area is labeled with an abbreviation and assigned a unique color. The colors can be used to show these cortical regions in other figures, such as the parcellated brain surfaces in the image to the right, so that the reader can quickly find the corresponding cortical areas on a geometrically accurate surface and see exactly how disparate the connected regions may be. Inside the cortical surface ring, the concentric circles each represent different attributes of the corresponding cortical regions. In order from outermost to innermost, these metric rings represent the grey matter volume, surface area, cortical thickness, curvature, and degree of connectivity (the relative proportion of fibers initiating or terminating in the region compared to the whole brain). Inside these circles, lines connect regions that are found to be structurally connected. The relative density (number of fibers) of these connections is reflected in the opacity of the lines, so that one can easily compare various connections and their structural importance at a glance. The fractional anisotropy of each connection is reflected in its color.[1]

UsesEdit

Brain MappingEdit

With the recent concerted push to map all of the human brain and its connections,[2][3] it has become increasingly important to find ways to graphically represent the large amounts of data involved in connectomics. Most other representations of the connectome use 3 dimensions, and therefore require an interactive graphical user interface.[1] The connectogram can display 83 cortical regions within each hemisphere, and visually display which areas are structurally connected, all on a flat surface. It is therefore simpler to keep in patient records, or to display in print mediums such as journal articles.

Clinical useEdit

File:Phineas Gage's Damage.jpeg

On an individual level, connectograms can be used to inform the treatment of patients with neuroanatomical abnormalities. Connectograms have been used to monitor the progression of neurological recovery of patients who suffered a traumatic brain injury (TBI).[4] They have also been applied to famous patient Phineas Gage, to estimate damage to his neural network (as well as the damage at the cortical level—the primary focus of earlier studies on Gage).[5]

Empirical StudyEdit

Connectograms can represent the averages of all of the cortical metrics (grey matter volume, surface area, cortical thickness, curvature, and degree of connectivity), as well as the average densities and fractional anisotropy of the connections, across populations of any size. This allows for quick visual and statistical comparison between groups such as males and females, differing age cohorts, or healthy controls and patients.

Modified VersionsEdit

There are many possibilities for which measures are included in the rings of a connectogram. Irimia and Van Horn (2012) have published connectograms which examine the correlative relationships between regions and uses the figures to compare the approaches of graph theory and connectomics.[6] Additional measures relating to neural networks[7] can be added as additional rings to the inside to show metrics of graph theory, as in the extended connectogram here:

Other usesEdit

Similar circular graph connections have been used to map many different types of information. Disease epidemics,[8] geographical networks,[9] beats in a song,[10] or, more commonly, genomic data.[11]

Regions and their AbbreviationsEdit

Acronym Region in connectogram
ACgG/S Anterior part of the cingulate gyrus and sulcus
ACirInS Anterior segment of the circular sulcus of the insula
ALSHorp Horizontal ramus of the anterior segment of the lateral sulcus (or fissure)
ALSVerp Vertical ramus of the anterior segment of the lateral sulcus (or fissure)
AngG Angular gyrus
AOcS Anterior occipital sulcus and preoccipital notch (temporo-occipital incisure)
ATrCoS Anterior transverse collateral sulcus
CcS Calcarine sulcus
CgSMarp Marginal branch (or part) of the cingulate sulcus
CoS/LinS Medial occipito-temporal sulcus (collateral sulcus) and lingual sulcus
CS Central sulcus (Rolando’s fissure)
Cun Cuneus
FMarG/S Fronto-marginal gyrus (of Wernicke) and sulcus
FuG Lateral occipito-temporal gyrus (fusiform gyrus)
HG Heschl’s gyrus (anterior transverse temporal gyrus)
InfCirInS Inferior segment of the circular sulcus of the insula
InfFGOpp Opercular part of the inferior frontal gyrus
InfFGOrp Orbital part of the inferior frontal gyrus
InfFGTrip Triangular part of the inferior frontal gyrus
InfFS Inferior frontal sulcus
InfOcG/S Inferior occipital gyrus and sulcus
InfPrCS Inferior part of the precentral sulcus
IntPS/TrPS Intraparietal sulcus (interparietal sulcus) and transverse parietal sulci
InfTG Inferior temporal gyrus
InfTS Inferior temporal sulcus
JS Sulcus intermedius primus (of Jensen)
LinG Lingual gyrus, lingual part of the medial occipito-temporal gyrus
LOcTS Lateral occipito-temporal sulcus
LoInG/CInS Long insular gyrus and central insular sulcus
LOrS Lateral orbital sulcus
MACgG/S Middle-anterior part of the cingulate gyrus and sulcus
MedOrS Medial orbital sulcus (olfactory sulcus)
MFG Middle frontal gyrus
MFS Middle frontal sulcus
MOcG Middle occipital gyrus, lateral occipital gyrus
MOcS/LuS Middle occipital sulcus and lunatus sulcus
MPosCgG/S Middle-posterior part of the cingulate gyrus and sulcus
MTG Middle temporal gyrus
OcPo Occipital pole
OrG Orbital gyri
OrS Orbital sulci (H-shaped sulci)
PaCL/S Paracentral lobule and sulcus
PaHipG Parahippocampal gyrus, parahippocampal part of the medial occipito-temporal gyrus
PerCaS Pericallosal sulcus (S of corpus callosum)
POcS Parieto-occipital sulcus (or fissure)
PoPl Polar plane of the superior temporal gyrus
PosCG Postcentral gyrus
PosCS Postcentral sulcus
PosDCgG Posterior-dorsal part of the cingulate gyrus
PosLS Posterior ramus (or segment) of the lateral sulcus (or fissure)
PosTrCoS Posterior transverse collateral sulcus
PosVCgG Posterior-ventral part of the cingulate gyrus (isthmus of the cingulate gyrus)
PrCG Precentral gyrus
PrCun Precuneus
RG Straight gyrus (gyrus rectus)
SbCaG Subcallosal area, subcallosal gyrus
SbCG/S Subcentral gyrus (central operculum) and sulci
SbOrS Suborbital sulcus (sulcus rostrales, supraorbital sulcus)
SbPS Subparietal sulcus
ShoInG Short insular gyri
SuMarG Supramarginal gyrus
SupCirInS Superior segment of the circular sulcus of the insula
SupFG Superior frontal gyrus
SupFS Superior frontal sulcus
SupOcG Superior occipital gyrus
SupPrCS Superior part of the precentral sulcus
SupOcS/TrOcS Superior occipital sulcus and transverse occipital sulcus
SupPL Superior parietal lobule
SupTGLp Lateral aspect of the superior temporal gyrus
SupTS Superior temporal sulcus
TPl Temporal plane of the superior temporal gyrus
TPo Temporal pole
TrFPoG/S Transverse frontopolar gyri and sulci
TrTS Transverse temporal sulcus
Amg Amygdala
CaN Caudate nucleus
Hip Hippocampus
NAcc Nucleus accumbens
Pal Pallidum
Pu Putamen
Tha Thalamus
CeB Cerebellum
BStem Brain stem

See alsoEdit

ReferencesEdit

  1. 1.0 1.1 Irimia, Andrei, Chambers, M.C., Torgerson, C.M., Van Horn, J.D. (2). Circular representation of human cortical networks for subject and population-level connectomic visualization. Neuroimage 60 (2): 1340–51.
  2. Human Connectome Project. NIH.
  3. includeonly>"Hard Cell", 9 March 2013. Retrieved on 11 March 2013.
  4. Irimia, Andrei, Chambers, M.C., Torgerson, C.M., Filippou, M., Hovda, D.A., Alger, J.R., Gerig, G., Toga, A.W., Vespa, P.M., Kikinis, R., Van Horn, J.D. (6). Patient-tailored connectomics visualization for the assessment of white matter atrophy in traumatic brain injury. Frontiers in Neurology 3: 10.
  5. Van Horn, John D., Irimia, A., Torgerson, C.M., Chambers, M.C., Kikinis, R., Toga, A.W. (16). Mapping connectivity damage in the case of Phineas Gage. PLoS One 7 (5): e37454.
  6. Irimia, Andrei, Jack Van Horn (29). The structural, connectomic, and network covariance of the human brain. Neuroimage 66: 489–499.
  7. Sporns, Olaf (2011). Networks of the Brain, MIT Press.
  8. Guo, Zhenyang, et al. (January 2013). National Borders Effectively Halt the Spread of Rabies: The Current Rabies Epidemic in China Is Dislocated from Cases in Neighboring Countries. PLoS Neglected Tropical Diseases 7 (1).
  9. Hennemann, Stefan (2013). Information-rich visualisation of dense geographical networks. Journal of Maps 9 (1): 1–8.
  10. Lamere, Paul The Infinite Jukebox. Music Machinery.
  11. Yip, Kevin, et al. (26). Classification of human genomic regions based on experimentally determined binding sites of more than 100 transcription-related factors. Genome Biology 13 (9).

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