Climbing fiber
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| Climbing fiber | |
|---|---|
 | |
| Location | Inferior Olive and Cerebellum |
| Function | Unique excitatory function (see text) |
| Morphology | Unique projection neuron (see text) |
| Presynaptic connections | Inferior olive |
| Postsynaptic connections | Purkinje cells |
| Gray's | subject #187 796 |
Climbing fibers are the name given to a series of neuronal projections from the inferior olivary nucleus located in the medulla.
These axons pass through the pons and enter the cerebellum where they form synapses with the deep cerebellar nuclei and Purkinje cells. Each climbing fiber will form synapses with 1-10 Purkinje cells.
Early in development, Purkinje cells are innervated by multiple climbing fibers, but as the cerebellum matures, these inputs gradually become eliminated resulting in a single climbing fiber input per Purkinje cell.
These fibers provide very powerful, excitatory input to the cerebellum which results in the generation of complex spikes in Purkinje cells.
Climbing fiber activation is thought to serve as a motor error signal sent to the cerebellum, and is an important signal for motor timing.
These Climbing fibres carry information to various sources such as the spinal cord, vestibular system, red nucleus, superior colliculus, reticular formation and sensory and motor cortices.
[edit] External links
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! Myelencephalon/
medulla
| colspan="1" style="text-align:left;width:100%;font-size:95%;background:#f7f7f7;" | {| class="navbox collapsible nowraplinks" style="margin:auto; background:white;background:white;"
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!| colspan="1" style="text-align:left;width:100%;font-size:95%;" | surface: Posterior median sulcus - Postero-lateral sulcus - Area postrema
cranial nuclei: GVA: VII,IX,X: Solitary/tract • SVA: Gustatory nucleus • GSE: XII • GVE: IX,X,XI: Ambiguus • SVE: X: Dorsal • IX: Inferior salivatory nucleus - MLF, III, IV and VI
sensory/ascending: Gracile nucleus • Cuneate nucleus (Accessory cuneate nucleus) • Sensory decussation • Medial lemniscus
motor/descending: Dorsal respiratory group
|- style="white-space:nowrap;background:#ddddff;text-align:right;padding-left:0em;padding-right:0em;background-color: LightYellow"
| colspan="1" style="text-align:left;width:100%;font-size:95%;background:#f7f7f7;" | motor/descending: Ventral respiratory group - Pyramid (Motor decussation) - Inferior olivary nucleus (Olivocerebellar tract, Rubro-olivary tract)
surface: Anterior median fissure - Antero-lateral sulcus - Arcuate nucleus of medulla - Olivary body
|- style="white-space:nowrap;background:#ddddff;text-align:right;padding-left:0em;padding-right:0em;background-color: LightYellow"
| colspan="1" style="text-align:left;width:100%;font-size:95%;" | Reticular formation (Gigantocellular, Parvocellular, Ventral, Lateral, Paramedian) • Raphe nuclei (Obscurus, Magnus, Pallidus) |} |}
| This page uses content from the English-language version of Wikipedia. The original article was at Climbing fiber. The list of authors can be seen in the page history. As with Psychology Wiki, the text of Wikipedia is available under the GNU Free Documentation License. |
