Chromosome 6 (human)

From Psychology Wiki

Community portal · Tasks to do · News · Help

Clinical · Educational · Ind&Org · Other fields · Professional · Transpersonal · World

Assessment | Biopsychology | Comparative | Cognitive | Developmental | Language
Personality | Philosophy | Research Methods | Social | Statistics

Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology

---

Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs (the building material of DNA) and represents between 5.5 and 6% of the total DNA in cells. It contains the Major Histocompatibility Complex, which contains over 100 genes related to the immune response, and plays a vital role in organ transplantation.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 6 likely contains between 1,100 and 1,600 genes.^{[citation needed]}

Contents 1 Genes 2 Diseases 3 References 4 Chromosome 6 in Fiction

[edit] Genes

The following are some of the genes located on chromosome 6:

• BCKDHB: branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease)
• COL11A2: collagen, type XI, alpha 2
• CYP21A2: cytochrome P450, family 21, subfamily A, polypeptide 2
• DSP: Desmoplakin gene linked to cardiomyopathy
• EYA4: eyes absent homolog 4 (Drosophila)
• HFE gene: hemochromatosis
• HLA-B: major histocompatibility complex, class I, B
• MUT: methylmalonyl Coenzyme A mutase
• MYO6: myosin VI
• PARK2: Parkinson disease (autosomal recessive, juvenile) 2, parkin
• PKHD1: polycystic kidney and hepatic disease 1 (autosomal recessive)
• TNXB: tenascin XB
• VEGF: vascular endothelial growth factor A (angiogenic growth factor)
• IGF2R: insulin-like growth factor 2 receptor

[edit] Diseases

The following diseases are some of those related to genes on chromosome 6:

• ankylosing spondylitis
• collagenopathy, types II and XI
• Ehlers-Danlos syndrome
• Ehlers-Danlos syndrome, classical type
• Ehlers-Danlos syndrome, hypermobility type
• hemochromatosis
• hemochromatosis, type 1
• 21-hydroxylase deficiency
• maple syrup urine disease
• methylmalonic acidemia
• nonsyndromic deafness
• nonsyndromic deafness, autosomal dominant
• nonsyndromic deafness, autosomal recessive
• otospondylomegaepiphyseal dysplasia
• Parkinson disease
• polycystic kidney disease
• porphyria
• porphyria cutanea tarda
• Stickler syndrome
• Stickler syndrome, COL11A2
• Weissenbacher-Zweymüller syndrome
• X-linked sideroblastic anemia

[edit] References

• Some text in this article was taken from http://ghr.nlm.nih.gov/chromosome=6 (public domain)
• Gilbert F (2002). Chromosome 6. Genet Test 6 (4): 341-58. PMID 12537662.
• Mungall AJ et alii (2003). The DNA sequence and analysis of human chromosome 6. Nature 425 (6960): 805-11. PMID 14574404.

[edit] Chromosome 6 in Fiction

Robin Cook's book, Chromosome 6, explores the possibility of transferring a little bit of human DNA onto very close relatives of the human, genetically wise, bonobos in this case, in order to create organs that would not be rejected by the human body. Chromosome six is mentioned due to the fact that HLA-B, the major histocompatibility complex, class I, B is present on it.

fr:Chromosome 6 humain

hu:Humán 6-os kromoszóma

pt:Cromossoma 6 (humano)

sr:Хромозом 6 (човек)

tr:kromozom 6

This page uses content from the English-language version of Wikipedia. The original article was at Chromosome 6 (human). The list of authors can be seen in the page history. As with Psychology Wiki, the text of Wikipedia is available under the GNU Free Documentation License.