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A synapse is cholinergic if it uses acetylcholine as its neurotransmitter.

Cholinergic means "related to the neurotransmitter acetylcholine". The parasympathetic nervous system is entirely cholinergic. A substance is cholinergic if it is capable of producing, altering, or releasing acetylcholine.

A cholinergic, also known as a cholinergic agent, cholinergic drug, or a parasympathomimetic, is any chemical which functions to enhance the effects mediated by acetylcholine in the central nervous system, the peripheral nervous system, or both. These include acetylcholine's precursors and cofactors, acetylcholine receptor agonists (such as muscarine and nicotine), as well as cholinergic enzymes such as the anticholinesterases.

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