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Individual differences |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |
Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
Like other transmembrane receptors, acetylcholine receptors are classified according to their "pharmacology", or according to their relative affinities and sensitivities to different molecules. Although all acetylcholine receptors, by definition, respond to acetylcholine, they respond to other molecules as well.
- nicotinic acetylcholine receptors (nAChR, also known as "ionotropic" acetylcholine receptors) are particularly responsive to nicotine
- muscarinic acetylcholine receptors (mAChR, also known as "metabotropic" acetylcholine receptors) are particularly responsive to muscarine.
The nAChRs are ion channels, and, like other members of the "cys-loop" ligand-gated ion channel superfamily, are composed of five protein subunits arranged like staves around a barrel. The subunit composition is highly variable across different tissues. Each channel contains two alpha subunits, a beta, a gamma, and a delta. Binding of acetylcholine to the N termini of each of the alpha subunits results in activation of the channel. Each subunit contains four regions named M1, M2, M3, and M4, which probably span the membrane. The M2 region, which sits closest to the pore lumen, forms the pore lining. The pore formed when the nAChR channel is open is permeable to both Na+ and K+ ions.
Role in health and diseaseEdit
Nicotinic acetylcholine receptors can be blocked by curare and toxins present in the venoms of snakes and shellfishes. Drugs such as the neuromuscular blocking agents bind reversibly to the nicotinic receptors in the neuromuscular junction and are used routinely in anaesthesia.
Nicotinic receptors are the main mediator of nicotine from tobacco addiction. In myasthenia gravis, the receptor is targeted by antibodies, leading to muscle weakness. Muscarinic acetylcholine receptors can be blocked by the drugs atropine and scopolamine.
References & BibliographyEdit
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