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Choline acetyltransferase

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choline acetyltransferase
Symbol(s): CHAT
Locus: 10 q11.2
EC number 2.3.1.6
EntrezGene 1103
OMIM 118490
RefSeq NM_020549
UniProt P28329

Choline acetyltransferase (EC 2.3.1.6) is an enzyme which is synthesized within the body of a neuron. It is then transferred to the nerve terminal via axoplasmic flow. It joins Acetyl CoA to choline, resulting in the formation of the neurotransmitter acetylcholine.

It is often used as a marker, immunohistochemically, for motor neurons (motoneurons).

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