Psychology Wiki


Redirected from Cholecystokinin tetrapeptide

34,203pages on
this wiki
Add New Page
Talk0 Share

Assessment | Biopsychology | Comparative | Cognitive | Developmental | Language | Individual differences | Personality | Philosophy | Social |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |

Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)

Cholecystokinin tetrapeptide (CCK-4, Trp-Met-Asp-Phe-NH2; also PTK7) is a peptide fragment derived from the larger peptide hormone cholecystokinin. Unlike cholecystokin which has a variety of roles in the gastrointenstinal system as well as central nervous system effects, CCK-4 acts primarily in the brain as an anxiogenic, although it does retain some GI effects, but not as much as CCK-8 or the full length polypeptide CCK-58.

CCK-4 reliably causes severe anxiety symptoms when administered to humans in a dose of as little as 50μg,[1] and is commonly used in scientific research to induce panic attacks for the purpose of testing new anxiolytic drugs.[2][3][4][5] Since it is a peptide, CCK-4 must be administered by injection, and is rapidly broken down once inside the body so has only a short duration of action,[6] although numerous synthetic analogues with modified properties are known.[7][8][9][10][11][12][13][14][15][16][17]

See alsoEdit


  1. Daniela Eser et al. (2005). Panic Induction with Cholecystokinin-Tetrapeptide (CCK-4) Increases Plasma Concentrations of the Neuroactive Steroid 3α, 5α Tetrahydrodeoxycorticosterone (3α, 5α-THDOC) in Healthy Volunteers. Neuropsychopharmacology 30 (1): 192–195.
  2. Bradwejn J. (July 1993). Neurobiological investigations into the role of cholecystokinin in panic disorder. Journal of Psychiatry and Neuroscience 18 (4): 178–188.
  3. Schunck T, Erb G, Mathis A, Gilles C, Namer IJ, Hode Y, Demaziere A, Luthringer R, Macher JP. (July 2006). Functional magnetic resonance imaging characterization of CCK-4-induced panic attack and subsequent anticipatory anxiety. NeuroImage 31 (3): 1197–1208.
  4. Eser D, Schüle C, Baghai T, Floesser A, Krebs-Brown A, Enunwa M, de la Motte S, Engel R, Kucher K, Rupprecht R. (July 2007). Evaluation of the CCK-4 model as a challenge paradigm in a population of healthy volunteers within a proof-of-concept study. Psychopharmacology 192 (4): 479–487.
  5. Eser D, Leicht G, Lutz J, Wenninger S, Kirsch V, Schüle C, Karch S, Baghai T, Pogarell O, Born C, Rupprecht R, Mulert C. (December 2007). Functional neuroanatomy of CCK-4-induced panic attacks in healthy volunteers. Human Brain Mapping 30 (2): 511–22.
  6. Koulischer D, Moroder L, Deschodt-Lanckman M (August 1982). Degradation of cholecystokinin octapeptide, related fragments and analogs by human and rat plasma in vitro. Regulatory Peptides 4 (3): 127–139.
  7. Blommaert AG, Dhôtel H, Ducos B, Durieux C, Goudreau N, Bado A, Garbay C, Roques BP (February 1997). Structure-based design of new constrained cyclic agonists of the cholecystokinin CCK-B receptor. Journal of Medicinal Chemistry 40 (5): 647–58.
  8. Bellier B, Million ME, DaNascimento S, Meudal H, Kellou S, Maigret B, Garbay C (October 2000). Replacement of glycine with dicarbonyl and related moieties in analogues of the C-terminal pentapeptide of cholecystokinin: CCK(2) agonists displaying a novel binding mode. Journal of Medicinal Chemistry 43 (20): 3614–23.
  9. Léna I, Dh tel H, Garbay C, Daugé V (January 2001). Involvement of D2 dopamine receptors in the opposing effects of two CCK-B agonists in a spatial recognition memory task: role of the anterior nucleus accumbens. Psychopharmacology 153 (2): 170–9.
  10. Bellier B, Garbay C (2003). How a single inversion of configuration leads to a reversal of the binding mode: proposal of a novel arrangement of CCK2 ligands in their receptor, and contribution to the development of peptidomimetic or non-peptide CCK2 ligands. European Journal of Medicinal Chemistry 38 (7-8): 671–86.
  11. Bellier B, Crété D, Million ME, Beslot F, Bado A, Garbay C, Daugé V (November 2004). New CCK2 agonists confirming the heterogeneity of CCK2 receptors: characterisation of BBL454. Naunyn-Schmiedeberg's Archives of Pharmacology 370 (5): 404–13.
  12. Proskuriakova TV, Bespalova ZhD, Pal'keeva ME, Petrichenko OB, Pankratova NV, Shokhonova VA, Anokhina IP (2005). [Biological activity of cholecystokinin-(30-33) tetrapeptide analogs]. Bioorganicheskaia Khimiia 31 (2): 130–9.
  13. Anokhina IP, Proskuriakova TV, Bespalova ZhD, Pal'keeva ME, Shokhonova VA, Petrichenko OB (2006). [Effect of a cholecystokinin tetrapeptide analogue on opioid reception under acute and chronic morphine administration]. Bioorganicheskaia Khimiia 32 (3): 276–83.
  14. Agnes RS, Lee YS, Davis P, Ma SW, Badghisi H, Porreca F, Lai J, Hruby VJ (May 2006). Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. Journal of Medicinal Chemistry 49 (10): 2868–75.
  15. Noble F (2007). Pharmacology of CCKRs and SAR studies of peptidic analog ligands. Current Topics in Medicinal Chemistry 7 (12): 1173–9.
  16. García-López MT, González-Muñiz R, Martín-Martínez M, Herranz R (2007). Strategies for design of non peptide CCK1R agonist/antagonist ligands. Current Topics in Medicinal Chemistry 7 (12): 1180–94.
  17. Kalindjian SB, McDonald IM (2007). Strategies for the design of non-peptide CCK2 receptor agonist and antagonist ligand. Current Topics in Medicinal Chemistry 7 (12): 1195–204.

This page uses Creative Commons Licensed content from Wikipedia (view authors).

Ad blocker interference detected!

Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers

Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.

Also on Fandom

Random Wiki