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Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
cholecystokinin A receptor | |
---|---|
Symbol(s): | CCKAR |
Locus: | 4 p15.2 -p15.1 |
EC number | [1] |
EntrezGene | 886 |
OMIM | 118444 |
RefSeq | NM_000730 |
UniProt | P32238 |
cholecystokinin B receptor | |
---|---|
Symbol(s): | CCKBR |
Locus: | 11 p15.4 |
EC number | [2] |
EntrezGene | 887 |
OMIM | 118445 |
RefSeq | NM_176875 |
UniProt | P32239 |
Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin.[1] There are two different subtypes CCKA and CCKB which are ~50% homologous:[2]
protein | gene | tissue distribution | preferred ligand | function |
---|---|---|---|---|
CCKA (CCK1) | CCKAR | primarily gastrointestinal tract, lesser amounts in the CNS | sulfated CCK >> nonsulfated CCK ≈ nonsulfated CCK | stimulation of gastric acid secretion, gastric emptying and gut motility |
CCKB (CCK2) | CCKBR | primarily CNS, lesser amounts in the gastrointestinal track | gastrin ≈ CCK (receptor does not descriminate between sulfated and nonsulfated peptides) | regulation of nociception, anxiety, memory and hunger |
References[]
- ↑ Noble F, Wank SA, Crawley JN, Bradwejn J, Seroogy KB, Hamon M, Roques BP (1999). International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors. Pharmacol. Rev. 51 (4): 745–81.
- ↑ Dufresne M, Seva C, Fourmy D (2006). Cholecystokinin and gastrin receptors. Physiol. Rev. 86 (3): 805–47.
External links[]
Neuropeptide receptors | |
---|---|
Hypothalamic hormone receptors |
CRH - FSH - LHRH - TRH - Somatostatin |
Pituitary hormone receptors |
Vasopressin (1A, 1B, 2) - Oxytocin - LHCG - Type I cytokine receptor (GH, Prolactin) - TSH |
Other hormone receptors |
Atrial natriuretic factor - Calcitonin - Cholecystokinin - VIP |
Opioid receptors |
Delta - Kappa - Mu - Sigma (1, 2) - Nociceptin |
Other neuropeptide receptors |
Angiotensin - Bradykinin/Tachykinin (TACR1) - Calcitonin gene-related peptide - Galanin - GPCR neuropeptide (B/W, FF, S, Y) - Neurotensin |
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