Cholecystokinin receptor
From Psychology Wiki
Community portal · Tasks to do · News · Help
Clinical · Educational · Ind&Org · Other fields · Professional · Transpersonal · World
Assessment |
Biopsychology |
Comparative |
Cognitive |
Developmental |
Language
Personality |
Philosophy |
Research Methods |
Social |
Statistics
Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology
| cholecystokinin A receptor | |
|---|---|
| Symbol(s): | CCKAR |
| Locus: | 4 p15.2 -p15.1 |
| EC number | [1] |
| EntrezGene | 886 |
| OMIM | 118444 |
| RefSeq | NM_000730 |
| UniProt | P32238 |
| cholecystokinin B receptor | |
|---|---|
| Symbol(s): | CCKBR |
| Locus: | 11 p15.4 |
| EC number | [2] |
| EntrezGene | 887 |
| OMIM | 118445 |
| RefSeq | NM_176875 |
| UniProt | P32239 |
Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin.[1] There are two different subtypes CCKA and CCKB which are ~50% homologous:[2]
| protein | gene | tissue distribution | preferred ligand | function |
|---|---|---|---|---|
| CCKA (CCK1) | CCKAR | primarily gastrointestinal tract, lesser amounts in the CNS | sulfated CCK >> nonsulfated CCK ≈ nonsulfated CCK | stimulation of gastric acid secretion, gastric emptying and gut motility |
| CCKB (CCK2) | CCKBR | primarily CNS, lesser amounts in the gastrointestinal track | gastrin ≈ CCK (receptor does not descriminate between sulfated and nonsulfated peptides) | regulation of nociception, anxiety, memory and hunger |
[edit] References
- ↑ Noble F, Wank SA, Crawley JN, Bradwejn J, Seroogy KB, Hamon M, Roques BP (1999). International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors. Pharmacol. Rev. 51 (4): 745–81.
- ↑ Dufresne M, Seva C, Fourmy D (2006). Cholecystokinin and gastrin receptors. Physiol. Rev. 86 (3): 805–47.
[edit] External links
Neuropeptide receptors | |
|---|---|
| Hypothalamic hormone receptors | CRH - FSH - LHRH - TRH - Somatostatin |
| Pituitary hormone receptors | Vasopressin (1A, 1B, 2) - Oxytocin - LHCG - Type I cytokine receptor (GH, Prolactin) - TSH |
| Other hormone receptors | Atrial natriuretic factor - Calcitonin - Cholecystokinin - VIP |
| Opioid receptors | Delta - Kappa - Mu - Sigma (1, 2) - Nociceptin |
| Other neuropeptide receptors | Angiotensin - Bradykinin/Tachykinin (TACR1) - Calcitonin gene-related peptide - Galanin - GPCR neuropeptide (B/W, FF, S, Y) - Neurotensin |
| This page uses content from the English-language version of Wikipedia. The original article was at Cholecystokinin receptor. The list of authors can be seen in the page history. As with Psychology Wiki, the text of Wikipedia is available under the GNU Free Documentation License. |
