Chlorzoxazone
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Chlorzoxazone chemical structure | |
| 5-chloro-3H-benzooxazol-2-one IUPAC name | |
| CAS number 95-25-0 | ATC code |
| PubChem 2733 | DrugBank APRD00308 |
| Chemical formula | {{{chemical_formula}}} |
| Molecular weight | 169.565 g/mol |
| Bioavailability | well absorbed |
| Metabolism | hepatic |
| Elimination half-life | 1.1 hr |
| Excretion | urine (<1%) |
| Pregnancy category | |
| Legal status | |
| Routes of administration | oral |
Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes. It is sold as Muscol or Parafon Forte, a combination of chlorzoxazone and acetaminophen. Possible side effects include dizziness, lightheadedness, malaise, nausea, vomiting, and liver dysfunction.
External links
Edit
- Dong DL, Luan Y, Feng TM, Fan CL, Yue P, Sun ZJ, Gu RM, Yang BF. (2006). Chlorzoxazone inhibit contraction of rat thoracic aorta.. Eur J Pharmacol.
- Park J, Kim K, Park P, Ha J (2006). Effect of high-dose aspirin on CYP2E1 activity in healthy subjects measured using chlorzoxazone as a probe.. J Clin Pharmacol 46 (1): 109–14.
- Wan J, Ernstgård L, Song B, Shoaf S (2006). Chlorzoxazone metabolism is increased in fasted Sprague-Dawley rats.. J Pharm Pharmacol 58 (1): 51–61.
Muscle relaxants (M03) | |
|---|---|
| Peripherally acting (primarily antinicotinic, neuromuscular-blocking drugs) |
curare alkaloids (Alcuronium, Dimethyltubocurarine, Tubocurarine) - choline derivatives (Suxamethonium) - other quaternary ammonium compounds (Atracurium, Cisatracurium, Doxacurium chloride, Fazadinium bromide, Gallamine, Hexafluronium, Mivacurium chloride, Pancuronium, Pipecuronium bromide, Rocuronium bromide, Vecuronium) - other (Botulinum toxin) |
| Centrally acting |
carbamic acid esters (Phenprobamate, Carisoprodol, Methocarbamol, Styramate, Febarbamate), Baclofen, Chlormezanone, Chlorzoxazone, Cyclobenzaprine, Lorazepam, Mephenesin, Orphenadrine, Phenyramidol, Pridinol, Tetrazepam, Thiocolchicoside, Tizanidine, Tolperisone |
| Directly acting | |
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