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Chlorzoxazone

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Chlorzoxazone chemical structure
Chlorzoxazone

5-chloro-3H-benzooxazol-2-one
IUPAC name
CAS number
95-25-0
ATC code

M03BB03

PubChem
2733
DrugBank
APRD00308
Chemical formula {{{chemical_formula}}}
Molecular weight 169.565 g/mol
Bioavailability well absorbed
Metabolism hepatic
Elimination half-life 1.1 hr
Excretion urine (<1%)
Pregnancy category
Legal status
Routes of administration oral

Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes. It is sold as Muscol or Parafon Forte, a combination of chlorzoxazone and acetaminophen. Possible side effects include dizziness, lightheadedness, malaise, nausea, vomiting, and liver dysfunction.

External linksEdit

  • Dong DL, Luan Y, Feng TM, Fan CL, Yue P, Sun ZJ, Gu RM, Yang BF. (2006). Chlorzoxazone inhibit contraction of rat thoracic aorta.. Eur J Pharmacol.
  • Park J, Kim K, Park P, Ha J (2006). Effect of high-dose aspirin on CYP2E1 activity in healthy subjects measured using chlorzoxazone as a probe.. J Clin Pharmacol 46 (1): 109–14.
  • Wan J, Ernstgård L, Song B, Shoaf S (2006). Chlorzoxazone metabolism is increased in fasted Sprague-Dawley rats.. J Pharm Pharmacol 58 (1): 51–61.


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