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Chloride channels are a superfamily of poorly understood ion channels consisting of approximately 13 members.

Chloride channels are important for setting cell resting membrane potential and maintaining proper cell volume. These channels conduct Cl^- as well as other anions such as HCO₃^-, I^-, SCN^-, and NO₃^-. The structure of these channels is also not other known channels. Chloride channel subunits contain between 1 and 12 transmembrane segments. Some members of this family are activated by voltage, while others are activated by Ca²⁺, extracellular ligands, and pH among other modulators.^[1]

GenesEdit

• CLCN1, CLCN2, CLCN3, CLCN4, CLCN5, CLCN6, CLCN7
• CLCNKA, CLCNKB
• CLIC1, CLIC2, CLIC3, CLIC4, CLIC5, CLIC6
• CLNS1A, CLNS1B
• CLCA1, CLCA2, CLCA3, CLCA4

See alsoEdit

• Cystic fibrosis transmembrane conductance regulator
• Thomsen disease

External linksEdit

• MeSH Chloride+channels

ReferencesEdit

• 1. ↑ Suzuki M., Morita T. and Iwamoto, T. (2006) Diversity of Cl(-) channels. Cell Mol Life Sci. 63(1):12-24. Entrez PubMed 16314923