Wikia

Psychology Wiki

Chemoaffinity hypothesis of neural development

Talk0
34,134pages on
this wiki
Revision as of 14:00, September 17, 2012 by Dr Joe Kiff (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)

Assessment | Biopsychology | Comparative | Cognitive | Developmental | Language | Individual differences | Personality | Philosophy | Social |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |

Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)


The Chemoaffinity hypothesis states that neurons make connections with their targets based on interactions with specific molecular markers[1] and, therefore, that the initial wiring diagram of an organism is (indirectly) determined by its genotype. The markers are generated during cellular differentiation and aid not only with synaptogenesis, but also act as guidance cues for their respective axon.[1]

Sperry's experiments

Roger Wolcott Sperry pioneered the inception of the Chemoaffinity Hypothesis following his 1960's experiments on the African Clawed Frog.[2] He removed the eye of a frog and rotated it 180°, Sperry then replaced the eye and the visual nervous system repaired itself.[3] However, the frog now had inverted vision. Initial eye orientation gives that the top of the eye is Dorsal, and the bottom is Ventral. Post-operation, the "top" of the eye is now Ventral, and the bottom is Dorsal. When a food source was above the frog, it extended its tongue downwards; meaning that the Dorsal-Ventral orientation of the eye still remained. [4] In follow up experiments, the eye was detached and rotated 180º and the optic nerve was also cut to see if this would affect the Dorsal-Ventral orientation. The results were identical. [citation needed]

Sperry concluded that each individual optic nerve and tectal neuron used some form of chemical marker which dictated their connectivity during development. He reasoned that when the eye had been rotated, each optic fiber and each tectal neuron possessed cytochemical labels that uniquely denoted their neuronal type and position and that optic fibers could utilize these labels to selectively navigate to their matching target cell, hence the visuomotor impairment.[2]

See also

References

  1. 1.0 1.1 BIO254:Chemoaffinity. OpenWetWare. URL accessed on 1 September 2011.Template:Rs
  2. 2.0 2.1 Ronald L. Meyer (1998). Roger Sperry and his Chemoaffinity Hypothesis. Neuropsychologia 36 (10): 957–980.
  3. Ferry, Gorgina (10 June 1989). The nervous system repairs to the network. NewScientist (1668).Template:Subscription
  4. Roger W. Sperry (1943). Effect of 180 Degree Rotation of the Retinal Field on Visuomotor Coordination. The Journal of Experimental Zoology 92 (3): 263–279.
This page uses Creative Commons Licensed content from Wikipedia (view authors).

Around Wikia's network

Random Wiki