From Psychology Wiki

Community portal · Tasks to do · News · Help

Clinical · Educational · Ind&Org · Other fields · Professional · Transpersonal · World

Assessment | Biopsychology | Comparative | Cognitive | Developmental | Language | Personality | Philosophy | Research Methods | Social | Statistics

Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology

---

Image:Carisoprodol-2D-skeletal.png Carisoprodol
[2-methyl-2-(1-methylethylcarbamoyloxymethyl) pentyl]aminomethanoate IUPAC name
CAS number 78-44-4	ATC code M03BA02
PubChem 2576	DrugBank APRD00417
Chemical formula	{{{chemical_formula}}}
Molecular weight	260.33 g/mol
Bioavailability
Metabolism	Hepatic (CYP2C19-mediated)
Elimination half-life	8 hours
Excretion	Renal
Pregnancy category
Legal status	Scheduled in some U.S. states
Routes of administration	Oral

Carisoprodol is a skeletal muscle relaxant whose active metabolite is meprobamate. Although several case reports have shown that carisoprodol has abuse potential, it continues to be widely prescribed (not so in the United Kingdom where use of benzodiazepines is preferred). Carisoprodol is a colorless, crystalline powder, having a mild, characteristic odor and a bitter taste. It is slightly soluble in water and freely soluble in alcohol, chloroform and acetone. Its solubility is practically independent of pH. It is marketed in the United States under the brand name Soma, and in the United Kingdom and other countries under the brand name Carisoma.

Contents 1 Chemistry 2 Effects 3 Side effects 4 Pharmacokinetics 5 References 6 External links

[edit] Chemistry

It is a carbamic acid ester. Carisoprodol is a racemic mixture of two stereoisomers.

[edit] Effects

• Analgesia
• Relief from hypertonia

[edit] Side effects

These are somewhat rare when used at normal doses.

• Somnolence
• Ataxia

[edit] Pharmacokinetics

Carisoprodol has a rapid, 30 minute onset of action, with the aforementioned effects lasting for approximately 2–6 hours. It is metabolized in the liver via the cytochrome P450 oxidase isozyme CYP2C19, excreted by the kidneys and has an approximate 8 hour half-life.

[edit] References

APhA Drug Information Handbook

[edit] External links

• Drug information

v·d·e Muscle relaxants (M03)
Peripherally acting (primarily antinicotinic, neuromuscular-blocking drugs)	curare alkaloids (Alcuronium, Dimethyltubocurarine, Tubocurarine) - choline derivatives (Suxamethonium) - other quaternary ammonium compounds (Atracurium, Cisatracurium, Doxacurium chloride, Fazadinium bromide, Gallamine, Hexafluronium, Mivacurium chloride, Pancuronium, Pipecuronium bromide, Rocuronium bromide, Vecuronium) - other (Botulinum toxin)
Centrally acting	carbamic acid esters (Phenprobamate, Carisoprodol, Methocarbamol, Styramate, Febarbamate), Baclofen, Chlormezanone, Chlorzoxazone, Cyclobenzaprine, Lorazepam, Mephenesin, Orphenadrine, Phenyramidol, Pridinol, Tetrazepam, Thiocolchicoside, Tizanidine, Tolperisone
Directly acting	Dantrolene

This page uses content from the English-language version of Wikipedia. The original article was at Carisoprodol. The list of authors can be seen in the page history. As with Psychology Wiki, the text of Wikipedia is available under the GNU Free Documentation License.