Wikia

Psychology Wiki

Carbamazepine

Talk0
34,140pages on
this wiki
Revision as of 22:44, May 9, 2007 by Dr Joe Kiff (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)

Assessment | Biopsychology | Comparative | Cognitive | Developmental | Language | Individual differences | Personality | Philosophy | Social |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |

Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)


Carbamazepine chemical structure
Carbamazepine

5H-dibenzepine-5-carboxamide
IUPAC name
CAS number
298-46-4
ATC code

N03AF01

PubChem
2554
DrugBank
APRD00337
Chemical formula {{{chemical_formula}}}
Molecular weight 236.269 g/mol
Bioavailability 80%
Metabolism hepatic CYP3A4 to active epoxide form
Elimination half-life 25-65 hours
Excretion 2-3% excreted unchanged in urine
Pregnancy category {{{pregnancy_category}}}
Legal status
Routes of administration oral


Carbamazepine (sold under the brand-names Biston, Calepsin, Carbatrol, Epitol, Equetro, Finlepsin, Sirtal, Stazepine, Tegretol, Telesmin, Timonil, sometimes abbreviated CBZ) is an anticonvulsant and mood stabilizing drug, used primarily in the treatment of epilepsy and bipolar disorder. It is also used to treat schizophrenia and trigeminal neuralgia.

Mechanisms

Carbamazepine and its derivatives' mechanism of action is relatively well understood. Voltage gated sodium channels are the molecular pores that allow brain cells (neurons) to generate action potentials, the electrical event that allows neurons to communicate over long distances. After the sodium channels open, to start the action potential, they inactivate, essentially closing the channel. Carbamazepine stabilizes the inactivated state of sodium channels, meaning that fewer sodium channels are available to open, making brain cells less excitable.

Adverse effects

Carbamazepine renders birth control pills ineffective because it is an enzyme inducer of the cytochrome P450 system which metabolises the oral contraceptive, leaving less active contraceptive in the plasma.

Common side effects include drowsiness, motor-coordination impairment and/or upset stomach. Taken every twelve hours, the Tegretol XR or Carbatrol preparations can greatly decrease alcohol tolerance.

Less common side effects include, cardiac arrythmias, blurry or double vision and/or the temporary or mild loss of blood cells or platelets. In rare cases the latter can be life-threatening if unnoticed, so frequent blood tests are required during the first few months' use, followed by three or four tests per year. In the UK testing would be less frequent in long-term use, typically once every year or two. Underactivity of the thyroid gland may be provoked, so thyroid function tests are advisable every year or two.

Small reductions in white cell count and serum sodium are common.

There are also reports of a bizarre auditory side effect, whereby patients perceive musical notes about a semitone lower than their actual pitch (so middle C would be heard as the note B3 just below it, etc).

Oxcarbazepine, a derivative of carbamazepine, has fewer and less serious side effects.

Carbamazepine can cause SIADH (syndrome of inappropriate antidiuretic hormone), since it both increases the release and potentiates the action of ADH (vasopressin).

Carbamazepine greatly reduces serum concentrations of simvastatin and simvastatin acid [ 1 ].

Carbamazepine may aggravate juvenile myoclonic epilepsy, so it is important to mention any history of jerking, especially in the morning, before starting to take this drug.

History

Carbamazepine was discovered by chemist Walter Schindler at J.R. Geigy AG (now part of Novartis) in Basel, Switzerland, in 1953. Schindler then synthesized the drug in 1960, before its anti-epileptic properties had been discovered.

Carbamazepine was first marketed as a drug to treat trigeminal neuralgia in 1962. It has been used as an anticonvulsant in the UK since 1965, but only approved in the U.S. since 1974.

If taken as meant as drug, side effects include double vision, euphoric feeling, drowsiness, and other mild side effects.

See also

References

Notes

  1. ^  M. Ucar et al (2004). Carbamazepine markedly reduces serum concentrations of simvastatin and simvastatin acid. Eur J Clin Pharmacol 59: 879–882.

Т

External links


Anticonvulsants edit





|-

Template:Aromatic allylic alcohol anticonvulsants Template:Carboxamides |-



|-



|- Template:Carbamates


|-


|- |}

This page uses Creative Commons Licensed content from Wikipedia (view authors).

Around Wikia's network

Random Wiki