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CCK receptor

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cholecystokinin A receptor
Symbol(s): CCKAR
Locus: 4 p15.2 -p15.1
EC number [1]
EntrezGene 886
OMIM 118444
RefSeq NM_000730
UniProt P32238
cholecystokinin B receptor
Symbol(s): CCKBR
Locus: 11 p15.4
EC number [2]
EntrezGene 887
OMIM 118445
RefSeq NM_176875
UniProt P32239

Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors. There are two different subtypes CCK1 and CCK2. They are ~50% homologous. The CCK1 receptor binds mostly to Cholecystokinin while CCK2 also binds to gastrin. They are mostly involved in various digestive functions like gastrin-stimulated gastric acid secretion, gastric emptying and gut motility. In the brain, CCK functions as a neuropeptide and CCK receptors are involved in nociception, anxiety, memory and hunger.

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