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Bombesin is a 14 amino acid peptide originally isolated from the skin of a frog. It has two known homologues in mammals called neuromedin B and gastrin releasing peptide. It works on the gastrointestinal tract neuroendocrine hormone and it stimulates gastrin release from G cells. It activates three different G-protein coupled receptors known as BBR1 2 & 3. It also activates these receptors in the brain. Together with cholecystokinin it is the second major source of negative feedback signals that stop eating behaviour.

Bombesin

IUPAC Name: (2S)-2-[[(2S)-2-amino-3-carbamoyl-propanoyl]amino]-N-[(1S)-1-[[(1S)-1-[[(1S)-1-[[(1S)-1-[[(1S)-1-[[(1S)-1-carbamoyl-3-methylsulfanyl-propyl]carbamoyl]-3-methyl-butyl]carbamoyl]-2-(3H-imidazol-4-yl)ethyl]carbamoylmethylcarbamoyl]-2-methyl-propyl]carbamoyl]ethyl]carbamoyl]-2-(1H-indol-3-yl)ethyl]pentanediamide

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