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Bipolar disorder - Genetic factors

Revision as of 15:28, 20 February 2007 by Dr Joe Kiff (Message Wall | contribs) (→‎Papers)
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Family studies

The role of genetic factors in bipolar disorder is indicated by concordance in monozygotic and dizygotic twins, respectively, of 57% and 14%, and the correlation between adopted people and their biological relatives (Cadoret, 1978).

Genetic mapping

Studies have explored the relationship between bipolar disorder and a large number of human chromosomes:

See also

References & Bibliography

Key texts

Books

Papers

Cadoret, R. J.(1978). Evidence for genetic inheritance of primary affective disorder in adoptees. Am. J. Psychiat. 135: 463-466, PMID 637144

  • Baron, M. (1977).Linkage between an X-chromosome marker (deutan color blindness) and bipolar affective illness: occurrence in the family of a lithium carbonate-responsive schizo-affective proband. Arch. Gen. Psychiat. 34: 721-725. PMID 301380
  • Baron, M., Freimer, N. F., Risch, N., Lerer, B., Alexander, J. R., Straub, R. E., Asokan, S., Das, K., Peterson, A., Amos, J., Endicott, J., Ott, J. and Gilliam, T. C.(1993).Diminished support for linkage between manic depressive illness and X-chromosome markers in three Israeli pedigrees. Nature Genet. 3: 49-55.

PMID 8490654

  • Baron, M., Rainer, J. D. and Risch, N. (1981).X-linkage in bipolar affective illness: perspectives on genetic heterogeneity, pedigree analysis and the X-chromosome map. J. Affect. Disorders 3: 141-157.PMID 6454708
  • Baron, M., Risch, N., Hamburger, R., Mandel, B., Kushner, S., Newman, M., Drumer, D. and Belmaker, R. H. (1987).Genetic linkage between X-chromosome markers and bipolar affective illness. Nature 326: 289-292.

PMID 3493438

  • Bertelsen, A., Harvald, B., Hauge, M. (1977).A Danish twin study of manic-depressive disorders. British Journal of Psychiatry 130: 330-351.PMID 558030
  • Cadoret, R. J.; Winokur, G. (1975). X-linkage in manic-depressive illness. Ann. Rev. Med. 26: 21-25.

PMID 1096758

  • Gejman, P. V., Detera-Wadleigh, S., Martinez, M. M., Berrettini, W. H., Goldin, L. R., Gelernter, J., Hsieh, W.-T.; Gershon, E. S. (1990). Manic depressive illness not linked to factor IX region in an independent series of pedigrees. Genomics 8: 648-655. PMID 1980485
  • Gershon, E. S., Bunney, W. E., Jr., Leckman, J. F., Van Eerdewegh, M. and De Bauche, B. A. (1976).The inheritance of affective disorders: a review of data and of hypotheses. Behavioural Genetetics 6: 227-261.

PMID 1086088

  • Gershon, E. S., Hamovit, J., Guroff, J. J., Dibble, E., Leckman, J. F., Sceery, W., Targum, S. D., Nurnberger, J. I. Goldin, L. R. and Bunney, W. E., Jr. (1982). A family study of schizo-affective, bipolar I, bipolar II, unipolar, and normal control probands. Arch. Gen. Psychiat. 39: 1157-1167 PMID 7125846
  • Hebebrand, J.(1992).A critical appraisal of X-linked bipolar illness: evidence for the assumed mode of inheritance is lacking. Brit. J. Psychiat. 160: 7-11. PMID 1544014
  • Hebebrand, J. and Hennighausen, K.(1992). A critical analysis of data presented in eight studies favouring X-linkage of bipolar illness with special emphasis on formal genetic aspects. Hum. Genet. 90: 289-293. PMID 1487243
  • Mendlewicz, J., Fleiss, J. L. and Fieve, R. R. (1972).Evidence for X-linkage in the transmission of manic-depressive illness. J.A.M.A. 222: 1624-1627.PMID 4539092
  • Mendlewicz, J.; Linkowski, P.; Wilmotte, J.(1980). Linkage between glucose-6-phosphate dehydrogenase deficiency and manic-depressive psychosis. Brit. J. Psychiat. 137: 337-342.PMID 7448473
  • Mendlewicz, J.; Rainer, J. D. (1974). Morbidity risk and genetic transmission in manic-depressive illness. Am. J. Hum. Genet. 26: 692-701.PMID 4548308
  • Mendlewicz, J.; Rainer, J. D. 1973. X-linkage in manic-depressive illness. (Letter) British Medical Journal. 3: 290.PMID 4541867
  • Mendlewicz, J., Simon, P., Sevy, S., Charon, F., Brocas, H., Legros, S., and Vassart, G. (1987). Polymorphic DNA marker on X chromosome and manic depression. Lancet I: 1230-1232,
  • Pauls, D. L. (1993). Behavioural disorders: lessons in linkage. Nature Genet. 3: 4-5.PMID 8490652
  • Reich, T. Clayton, P. J. and Winokur, G. (1969). Family history studies. V. The genetics of mania. American Journal of Psychiatry 125: 1358-1369.PMID 5304735
  • Risch, N., Baron, M. and Mendlewicz, J. (1986). Assessing the role of X-linked inheritance in bipolar-related major affective disorder. J. Psychiat. Res. 20: 275-288.PMID 3806423
  • Smeraldi, E. Negri, F. Heimbuch, R. C. and Kidd, K. K. (1981). Familial patterns and possible modes of inheritance of primary affective disorders. J. Affect. Disorders 3: 173-182.PMID 6454711
  • Thomson, P. A., Wray, N. R., Thomson, A. M., Dunbar, D. R., Grassie, M. A., Condie, A., Walker, M. T., Smith, D. J., Pulford, D. J., Muir, W., Blackwood, D. H. R., Porteous, D. J. (2005).Sex-specific association between bipolar affective disorder in women and GPR50, and X-linked orphan G protein-coupled receptor. Molec. Psychiat. 10: 470-478,
  • Winokur, G.; Tanna, V. L. (1969).Possible role of X-linked dominant factor in manic depressive disease. Dis. Nerv. Syst. 30: 89-94.PMID 4975420

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