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Changes: Benztropine

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Some studies suggest that use of anticholinergics increases the risk of [[tardive dyskinesia]], a long-term side effect of antipsychotics.<!--
 
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Latest revision as of 18:54, May 7, 2011

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[[Image:|220px|Benztropine chemical structure]]
Benztropine

3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane
IUPAC name
CAS number
86-13-5
ATC code

N04AC01

PubChem
331152
DrugBank
APRD00748
Chemical formula {{{chemical_formula}}}
Molecular weight 307.429 g/mol
Bioavailability
Metabolism
Elimination half-life 3-6 hours
Excretion
Pregnancy category C
Legal status
Routes of administration oral, IM, IV

Benztropine (Cogentin®) is an anticholinergic drug principally used for the treatment of:

IndicationsEdit

It is used in patients with schizophrenia to reduce the side effects of antipsychotic treatment, such as parkinsonism and akathisia.

Benztropine is also a second-line drug for the treatment of Parkinson's disease. It improves tremor but not rigidity or bradykinesia.

Benztropine is also sometimes used for the treatment of dystonia, a rare disorder that causes abnormal muscle contraction, resulting in twisting postures of limbs, trunk, or face.

Side effectsEdit

These are principally anticholinergic:

Some studies suggest that use of anticholinergics increases the risk of tardive dyskinesia, a long-term side effect of antipsychotics.[1][2] Other studies have found no association between anticholinergic exposure and risk of developing tardive dyskinesia.[3]


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