Benztropine
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[[Image:|220px|Benztropine chemical structure]] | |
| 3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane IUPAC name | |
| CAS number 86-13-5 | ATC code |
| PubChem 331152 | DrugBank APRD00748 |
| Chemical formula | {{{chemical_formula}}} |
| Molecular weight | 307.429 g/mol |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | 3-6 hours |
| Excretion | |
| Pregnancy category | C |
| Legal status | |
| Routes of administration | oral, IM, IV |
Benztropine (Cogentin®) is an anticholinergic drug principally used for the treatment of:
- Drug-induced parkinsonism, akathisia and acute dystonia;
- Parkinson disease; and
- Idiopathic or secondary dystonia.
[edit] Indications
It is used in patients with schizophrenia to reduce the side effects of antipsychotic treatment, such as parkinsonism and akathisia.
Benztropine is also a second-line drug for the treatment of Parkinson's disease. It improves tremor but not rigidity or bradykinesia.
Benztropine is also sometimes used for the treatment of dystonia, a rare disorder that causes abnormal muscle contraction, resulting in twisting postures of limbs, trunk, or face.
[edit] Side effects
These are principally anticholinergic:
- Dry mouth
- Blurred vision
- Cognitive changes
- Constipation
- Urinary retention
- Tachycardia
- Anorexia
- Psychosis (usually in overdose)
Some studies suggest that use of anticholinergics increases the risk of tardive dyskinesia, a long-term side effect of antipsychotics.[1][2] Other studies have found no association between anticholinergic exposure and risk of developing tardive dyskinesia.[3]
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