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{{BioPsy}}
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'''Basal metabolic rate''' ('''BMR''') is the amount of energy expended while at rest in a neutrally temperate environment, in the post-absorptive state (meaning that the digestive system is inactive, which requires about twelve hours of fasting in humans). The release of energy in this state is sufficient only for the functioning of the vital organs, such as the heart, lungs, brain and the rest of the nervous system, liver, kidneys, sex organs, muscles and skin. BMR decreases with age and with the loss of lean body mass. Increased [[cardiovascular exercise]] and muscle mass can increase BMR. Illness, previously consumed food and beverages, environmental temperature, and stress levels can affect one's overall energy expenditure, and can affect one's BMR.
   
'''Basal metabolic rate''' ('''BMR''') is the amount of energy expended while an animal is at rest in a neutrally temperate environment, in the post-absorptive state (meaning that the digestive system is inactive, which requires about twelve hours of fasting in humans). The release of energy in this state is sufficient only for the functioning of the vital organs, such as the brain, skin, heart, muscles, liver, sex organs, lungs, nervous system, and kidneys. BMR decreases with age and with the loss of lean body mass. Increased [[cardiovascular exercise]] and muscle mass can increase BMR. Illness, previously consumed food and beverages, environmental temperature, and stress levels can affect ones overall energy expenditure, but does not affect one's BMR. An accurate BMR measurement requires that the person's [[sympathetic nervous system]] is not stimulated. Basal metabolic rate is measured under very restrictive circumstances. A more common and closely related measurement, used under less strict conditions, is '''resting metabolic rate''' ('''RMR'''). [http://www.caloriesperhour.com/faqs_BMR.html]
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BMR is measured under very restrictive circumstances when a person is awake, but at complete rest. An accurate BMR measurement requires that the person's [[sympathetic nervous system]] not be stimulated. A more common and closely related measurement, used under less strict conditions, is resting metabolic rate''' ('''RMR''').<ref>{{cite web
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| author=CaloriesPerHour.com
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| title=Diet and Weight Loss Tutorial
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| work=Calculating BMR and RMR
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| url=http://www.caloriesperhour.com/tutorial_BMR.php
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| accessdate=2008-01-26}}</ref>
   
BMR and RMR are measured by gas analysis through either direct or indirect [[calorimetry]], though a rough estimation can be acquired through an equation using age, sex, height, and weight. Studies of energy metabolism using both methods provide convincing evidence for the validity of the [[respiratory quotient]] (R.Q.), which measures the inherent composition and utilization of [[carbohydrate|carbohydrates]], [[fat|fats]] and [[protein|proteins]] as they are converted to energy substrate units that can be utilized by the body for energy.
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BMR and RMR are measured by gas analysis through either direct or indirect [[calorimetry]], though a rough estimation can be acquired through an equation using age, sex, height, and weight. Studies of energy metabolism using both methods provide convincing evidence for the validity of the [[respiratory quotient]] (R.Q.), which measures the inherent composition and utilization of [[carbohydrate]]s, [[fat]]s and [[protein]]s as they are converted to energy substrate units that can be used by the body as energy.
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==Nutrition and dietary considerations==
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Basal metabolic rate is usually by far the largest component of total caloric expenditure. However, the Harris-Benedict equations are only approximate and variation in BMR (reflecting varying body composition), in physical activity levels, and in energy expended in thermogenesis make it difficult to estimate the dietary consumption any particular individual needs in order to maintain body weight. 2000 kilocalories is often quoted but is no more than a guideline.
   
 
==Physiology==
 
==Physiology==
Both basal metabolic rate and resting metabolic rate are usually expressed in terms of daily rates of energy expenditure. The early work of the scientists J. Arthur Harris and Francis G. Benedict showed that average values could be derived using [[body surface area]] (computed from height and weight), age, and gender, along with the oxygen and carbon dioxide measures taken from calorimetry. Studies also showed that by eliminating the gender differences that occur with the accumulation of [[adipose tissue]] by expressing metabolic rate per unit of "fat-free" or lean body weight, the values between genders for basal metabolism are essentially the same. [[Exercise physiology]] textbooks have tables to show the conversion of height and body surface area as they relate to weight and basal metabolic values.
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Both basal metabolic rate and resting metabolic rate are usually expressed in terms of daily rates of energy expenditure. The early work of the scientists J. Arthur Harris and Francis G. Benedict showed that approximate values could be derived using [[body surface area]] (computed from height and weight), age, and sex, along with the oxygen and carbon dioxide measures taken from calorimetry. Studies also showed that by eliminating the sex differences that occur with the accumulation of [[adipose tissue]] by expressing metabolic rate per unit of "fat-free" or lean body weight, the values between sexes for basal metabolism are essentially the same. [[Exercise physiology]] textbooks have tables to show the conversion of height and body surface area as they relate to weight and basal metabolic values.
   
The primary organ responsible for regulating metabolism is the [[hypothalamus]]. The hypothalamus is located on the [[brain stem]] and forms the floor and part of the lateral walls of the third ventricle of the [[cerebrum]]. The chief functions of the hypothalamus are:
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The primary organ responsible for regulating metabolism is the [[hypothalamus]]. The hypothalamus is located on the [[brain stem]] and forms the floor and part of the lateral walls of the third ventricle of the [[cerebrum]]. The chief functions of the hypothalamus are:
   
1) control and integration of activities of the [[autonomic nervous system]] (ANS), The ANS regulates contraction of smooth muscle and cardiac muscle, along with secretions of many endocrine organs such as the thyroid gland (associated with many metabolic disorders). Through the ANS, the hypothalamus is the main regulator of visceral activities, such as heart rate, movement of food through the gastrointestinal tract, and contraction of the urinary bladder.
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:#control and integration of activities of the [[autonomic nervous system]] (ANS)
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:#*The ANS regulates contraction of smooth muscle and cardiac muscle, along with secretions of many endocrine organs such as the thyroid gland (associated with many metabolic disorders).
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:#*Through the ANS, the hypothalamus is the main regulator of visceral activities, such as heart rate, movement of food through the gastrointestinal tract, and contraction of the urinary bladder.
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:#production and regulation of feelings of rage and aggression
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:#regulation of body temperature
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:#regulation of food intake, through two centers:
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:#*The feeding center or hunger center is responsible for the sensations that cause us to seek food. When sufficient food or substrates have been received and [[leptin]] is high, then the satiety center is stimulated and sends impulses that inhibit the feeding center. When insufficient food is present in the stomach and [[ghrelin]] levels are high, receptors in the hypothalamus initiate the sense of hunger.
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:#*The thirst center operates similarly when certain cells in the hypothalamus are stimulated by the rising [[osmotic pressure]] of the extracellular fluid. If thirst is satisfied, osmotic pressure decreases.
   
2) to produce or regulate feelings of rage and aggression.
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All of these functions taken together form a survival mechanism that causes us to sustain the body processes that BMR and RMR measure.
   
3) to regulate body temperature.
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===BMR estimation formulas===
   
4) to regulate food intake, through two centers. The feeding center or hunger center is responsible for the sensations that cause us to seek food. When sufficient food or substrates have been received, then the satiety center is stimulated and sends impulses that inhibit the feeding center. The thirst center operates similarly when certain cells in the hypothalamus are stimulated by the rising [[osmotic pressure]] of the extracellular fluid. If thirst is satisfied, osmotic pressure decreases.
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Several prediction equations exist. Historically most notable was Harris-Benedict equation, which was created in 1919.
   
All of these functions taken together form a survival mechanism that causes us to sustain the body processes that BMR and RMR measure.
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The original equations from Harris and Benedict are:
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:*for men, <math>h = 66.4730+(13.7516\cdot w)+(5.0033\cdot s)-(6.7550\cdot a)</math>
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:*for women, <math>h = 655.0955+(9.5634\cdot w)+(1.8496\cdot s)-(4.6756\cdot a)</math>
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where ''h'' = total heat production per 24 hours at complete rest in [[calorie | kilocalorie]]s (kcal),
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''w'' = weight in [[kilogram]]s, ''s'' = stature (height) in [[centimeter]]s, and ''a'' = age in [[year]]s, and with the difference in BMR for men and women being mainly due to differences in body weight.<ref name="Harris1918">{{cite journal
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| author = Harris J, Benedict F
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| title = A Biometric Study of Human Basal Metabolism.
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| journal = Proc Sci U S A
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| volume = 4
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| issue = 12
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| pages = 370-3
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| year = 1918
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| id = PMID 16576330
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}}</ref>
   
As an example, for a 55-year-old woman, an estimated BMR might be 32 kilocalories (kcal) per square meter per hour. If her body surface area were 1.4 , the hourly energy expenditure would be 44.8 kcal/h (32 kcal/(m²·h) x 1.4 m²). This amounts to an energy expenditure of 1075 kcal per day (44.8 kcal x 24). The value of 1075 kilocalories, then, is the resting metabolic rate; or, if the more stringent measurement conditions were met, it could also be the basal metabolic rate.
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It was the best prediction equation until recently, when MD Mifflin and ST St Jeor [http://www.ajcn.org/cgi/content/abstract/51/2/241 in 1990 created] new equation:
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:* <math>h = (9.99\cdot weight)+(6.25\cdot height)-(4.92\cdot age)+166\cdot sex (1 for males; 0 for females)-161</math>
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During the last 100 years, lifestyles have changed and [http://www.adajournal.org/article/PIIS0002822305001495/abstract a survey in 2005] showed it to be about 5% more accurate.
   
==Nutrition and dietary considerations==
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===Example calculation===
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For example, a 55 year old woman weighing 130 lb (59 kg) and 5 feet 6 inches (168 cm) tall would have a BMR of 1266 kcal per day or 52.8 kcal/h (61.3 [[watt]]s). This is computed by as 655 + (9.6 x 59) + (1.8 x 168) - (4.7 x 55).
   
The primary substrates that supply the body with energy for basal metabolic measurement are carbohydrates, fats, and proteins. Each of these substrates have been measured for their caloric values in a bomb calorimeter, which determines exact values for energy in units of heat that are expressed as calories. A [[calorie]] is the amount of heat needed to raise the temperature of one kilogram of water by one degree Celsius. Chemists often use a small calorie based on the gram rather than the kilogram. The large Calorie (capital "C") is often called a kilocalorie (kcal), which is one thousand small calories. The "calorie" content of food is actually expressed in terms of large calories, whether called Calories or kilocalories.
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To calculate Daily Calorie Needs, this BMR value is multiplied by a factor with a value between 1.2 and 1.9, depending on the person's activity level.
   
At restaurants, it has become popular to provide customers with "Nutrition Facts" that explain the "caloric content" of each menu item. One popular restaurant chain describes its hamburger as having a serving size of 105 grams and containing 280 calories. Ninety calories are described as being from fat and four of those calories from saturated fat. The list is further subdivided into where the grams come from in the total weight content: 30 milligrams of cholesterol, 550 milligrams of sodium, 36 grams of carbohydrates, 2 grams of dietary fiber, and 7 grams of sugar. If a person knew their BMR or RMR, they could calculate what amount of caloric content and weight would satisfy their body's basic survival needs, and what excess or deficit would render a weight gain or weight loss (ignoring the [[thermic effect of food]], and effect from activity).
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An online BMR calculator for both metric and non-metric values can be found at this link [http://www.bmi-calculator.net/bmr-calculator/]
   
==Biochemistry==
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===Animal BMR===
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[[Kleiber's law]] relates the BMR for animals of different sizes and the observations indicate that the BMR is proportional to the 3/4 power of body mass. [[Warm blooded]], [[cold blooded]] and [[unicellular]] animals fit on different curves.
   
About 70% of a human's total energy expenditure is due to the basal life processes within the organs of the body: liver, 27%; brain, 19%; heart, 7%; kidneys, 10%; skeletal muscle, 18%; other organs, 19%. About 20% of one's energy expediture comes from physical activity and another 10% from [[thermogenesis]], or digestion of food. All of these processes require the body to process all of our substrates with oxygen and then to consume the production that occurs as carbon dioxide which is explained by the Krebs cycle. So the value of our food is certainly there for our survival, but there are relative meanings to how the body uses energy to keep our organs functioning normally based on the rate of oxygen needed to break down food biochemically.
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==Biochemistry==
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{{Unreferencedsection|date=April 2008}}
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{| align=right border="1" cellpadding="5" cellspacing="0"
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|-
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! colspan="2" |Energy expenditure breakdown
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|-
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|[[liver]]
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|27%
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|-
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|[[brain]]
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|19%
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|-
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|[[heart]]
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|7%
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|-
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|[[kidneys]]
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|10%
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|-
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|[[skeletal muscle]]
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|18%
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|-
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|other organs
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|19%
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|}
   
For example, because the ratio of hydrogen to oxygen atoms in all carbohydrates is always the same as that in water that is, 2 to 1 all of the oxygen consumed by the cells is used to oxidize the carbon in the carbohydrate molecule to form carbon dioxide. Consequently, during the complete [[oxidation]] of a glucose molecule, six molecules of carbon dioxide are produced and six molecules of oxygen are consumed.
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About 70% of a human's total energy expenditure is due to the basal life processes within the organs of the body (see table). About 20% of one's energy expenditure comes from physical activity and another 10% from [[thermogenesis]], or digestion of food.{{Fact|date=April 2007}} All of these processes require an intake of oxygen along with coenzymes to provide energy for survival (usually from macronutrients like carbohydrates, fats, and proteins) and expel carbon dioxide, which is explained by the [[Krebs cycle]].
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What enables the Krebs cycle to perform metabolic changes to fats, carbohydrates, and proteins is energy which can be defined as the ability or capacity to do work. The breakdown of large molecules into smaller molecules associated with release of energy is catabolism. The building up process is termed anabolism. The breakdown of proteins into amino acids is an example of catabolism while the formation of proteins from amino acids is an anabolic process.
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Exergonic reactions are energy-releasing reactions and are generally catabolic. Endergonic reactions require energy and include anabolic reactions and the contraction of muscle. Metabolism is the total of all catabolic, exergonic, anabolic, endergonic reactions.
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Adenosine Triphosphate (ATP) is the intermediate molecule that drives the exergonic transfer of energy to switch to endergonic anabolic reactions used in muscle contraction. This is what causes muscles to work which can require a breakdown, and also to build in the rest period, which occurs during the strengthening phase associated with muscular contraction. ATP is composed of adenine, a nitrogen containing base, ribose, a five carbon sugar (collectively called adenosine), and three phosphate groups. ATP is a high energy molecule because it stores large amounts of energy in the chemical bonds of the two terminal phosphate groups. The breaking of these chemical bonds in the Krebs Cycle provides the energy needed for muscular contraction.
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===Glucose===
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Because the ratio of hydrogen to oxygen atoms in all carbohydrates is always the same as that in water — that is, 2 to 1 — all of the oxygen consumed by the cells is used to oxidize the carbon in the carbohydrate molecule to form carbon dioxide. Consequently, during the complete [[oxidation]] of a glucose molecule, six molecules of carbon dioxide are produced and six molecules of oxygen are consumed.
   
 
The overall equation for this reaction is:
 
The overall equation for this reaction is:
   
:C<sub>6</sub>H<sub>12</sub>O<sub>6</sub> + 6 O<sub>2</sub> &rarr; 6 CO<sub>2</sub> + 6 H<sub>2</sub>O
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:C<sub>6</sub>H<sub>12</sub>O<sub>6</sub> + 6 O<sub>2</sub> 6 CO<sub>2</sub> + 6 H<sub>2</sub>O
   
 
Because the gas exchange in this reaction is equal, the respiratory quotient for carbohydrate is unity or 1.0:
 
Because the gas exchange in this reaction is equal, the respiratory quotient for carbohydrate is unity or 1.0:
   
:R.Q. = 6 CO<sub>2</sub> / 6 O<sub>2</sub>
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:R.Q. = 6 CO<sub>2</sub> / 6 O<sub>2</sub>
   
The chemical composition for fats differs from that of carbohydrates in that fats contain considerably fewer oxygen atoms in proportion to atoms of carbon and hydrogen. Fats are generally divided into six categories: total fats, [[saturated fatty acid]], [[polyunsaturated fatty acid]], [[unsaturated fat|monounsaturated fatty acid]], dietary [[cholesterol]], and [[trans fatty acid]]. From a basal metabolic or resting metabolic perspective, more energy is needed to burn a saturated fatty acid than an unsaturated fatty acid. The fatty acid molecule is broken down and categorized based on the number of carbon atoms in its molecular structure. The chemical equation for metabolism of the twelve to sixteen carbon atoms in a saturated fatty acid molecule shows the difference between metabolism of carbohydrates and fatty acids. [[Palmitic acid]] is a commonly studied example of the saturated fatty acid molecule. When palmitic acid is broken down, more oxygen is needed and more carbon dioxide is produced, but the respiratory quotient moves below unity to account for the increased energy required to burn fat molecules (generally nine calories per gram of fat versus four calories for a gram of carbohydrate or protein.)
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===Fats===
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The chemical composition for fats differs from that of carbohydrates in that fats contain considerably fewer oxygen atoms in proportion to atoms of carbon and hydrogen. When listed on nutritional information tables, fats are generally divided into six categories: total fats, [[saturated fatty acid]], [[polyunsaturated fatty acid]], [[unsaturated fat|monounsaturated fatty acid]], dietary [[cholesterol]], and [[trans fatty acid]]. From a basal metabolic or resting metabolic perspective, more energy is needed to burn a saturated fatty acid than an unsaturated fatty acid. The fatty acid molecule is broken down and categorized based on the number of carbon atoms in its molecular structure. The chemical equation for metabolism of the twelve to sixteen carbon atoms in a saturated fatty acid molecule shows the difference between metabolism of carbohydrates and fatty acids. [[Palmitic acid]] is a commonly studied example of the saturated fatty acid molecule. When palmitic acid is broken down, more oxygen is needed and more carbon dioxide is produced, but the respiratory quotient moves below unity to account for the increased energy required to burn fat molecules (generally nine kilocalories per gram of fat versus four kilocalories for a gram of carbohydrate or protein.)
   
 
The overall equation for the substrate utilization of palmitic acid is:
 
The overall equation for the substrate utilization of palmitic acid is:
:C<sub>16</sub>H<sub>32</sub>O<sub>2</sub> + 23 O<sub>2</sub> &rarr; 16 CO<sub>2</sub> + 16 H<sub>2</sub>O
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:C<sub>16</sub>H<sub>32</sub>O<sub>2</sub> + 23 O<sub>2</sub> 16 CO<sub>2</sub> + 16 H<sub>2</sub>O
   
 
Thus the R.Q. for palmitic acid is 0.696:
 
Thus the R.Q. for palmitic acid is 0.696:
   
:R.Q. = 16 CO(2) / 23 O<sub>2</sub> = 0.696
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:R.Q. = 16 CO<sub>2</sub> / 23 O<sub>2</sub> = 0.696
   
==Exercise physiology==
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===Proteins===
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Proteins are composed of carbon, hydrogen, oxygen, and nitrogen arranged in a variety of ways to form a large combination of [[amino acids]]. Unlike fat the body has no storage deposits of protein. All of it is contained in the body as important parts of tissues, blood hormones, and enzymes. The structural components of the body that contain these amino acids are continually undergoing a process of breakdown and replacement. The respiratory quotient for protein metabolism can be demonstrated by the chemical equation for oxidation of albumin:
   
There are several companies testing the public for this value to assist with weight loss. It is theorized that if a person can more accurately know what amount of energy is needed to survive, then a person can select consumption patterns to more efficiently match what is required by the body for daily activities. Thus the emphasis shifts from caloric restriction, which slows the BMR or RMR and causes frustration of weight management goals, to substrate utilization, which focuses on what the body needs to stay healthy. By measuring the carbon dioxide expended (''V''CO<sub>2</sub>) in ml/min and dividing that by oxygen consumed (''V''O<sub>2</sub>) in ml/min you can determine the R.Q., which can then be compared to heart rate for purposes of application.
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C<sub>72</sub>H<sub>112</sub>N<sub>2</sub>O<sub>22</sub>S + 77 O<sub>2</sub> 63 CO<sub>2</sub> + 38 H<sub>2</sub>O + SO<sub>3</sub> + 9 CO(NH<sub>2</sub>)<sub>2</sub>
   
What brings interest to the study of basal metabolism or resting metabolism are the paradoxes. For example, there are formulas for prediction which have many contradictory outcomes. If muscle is the principle determinant of resting metabolism, why does metabolic rate go up when we gain weight, including fat, and become weaker physically due to loss of muscle mass from caloric restriction? Why does metabolism go up when we drink coffee which has no appreciable effect on muscle gain? Why is metabolism perceived to be different between cultures, requiring different formulas to be devised by scientists with equipment that measures the rate with extreme precision? Why do we assume that 2,000 kilocalories daily is the standard amount of energy needed for a woman to survive, and 2,500 for a man, when the basal metabolic rates are so different in all the studies that are performed on this topic each year? Do the formulas of Harris and Benedict apply to seniors, when the subjects of the original work done at the Carnegie Institute of Washington D.C. in 1914 were college-age students?
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The R.Q. for albumin is 63 CO<sub>2</sub>/ 77 O<sub>2</sub> = 0.818
   
==Medical considerations==
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The reason why this is important in the process of understanding protein metabolism is because the body can blend the three macronutrients and based on the mitochondrial density, a preferred ratio can be established which determines how much fuel is utilized in which packets for work accomplished by the muscles. Protein catabolism (breakdown) has been estimated to supply 10% to 15% of the total energy requirement during a two hour training session. However, if a person's muscle glycogen supplies are low from previous exercise sessions, the amount of energy derived from protein catabolism could increase from 15% to 45%. This process could severely degrade the protein structures needed to maintain survival such as contractile properties of proteins in the heart, cellular mitochondria, myoglobin storage, and metabolic enzymes within muscles.
   
That is why weight management is a very difficult undertaking requiring sophisticated expertise. Each person is unique based on their structure and behavior and their metabolism is also unique. Menopause affects metabolism but in different ways for different people. Weight training can have a longer impact on metabolism than aerobic training, but there are no formulas currently written which can predict the length and duration of a raised metabolism from trophic changes with anabolic neuromuscular training. Careful graphing of the body's response to rest or exercise with a gas analyser that also records heart rate is one method that scientists use to measure the variation in basal metabolic rate between subjects.
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The oxidative system (aerobic) is the primary source of ATP supplied to the body at rest and during low intensity activities and uses primarily carbohydrates and fats as substrates. Protein is not normally metabolized significantly, except during long term starvation and long bouts of exercise (greater than 90 minutes.) At rest approximately 70% of the ATP produced is derived from fats and 30% from carbohydrates. Following the onset of activity, as the intensity of the exercise increases, there is a shift in substrate preference from fats to carbohydrates. During high intensity aerobic exercise, almost 100% of the energy is derived from carbohydrates, if an adequate supply is available.
   
Gastric bypass surgery also has implications because it affects the storage capacity of the body by reducing the contents of the stomach to about the size of a thumb and "bypasses" the majority of the stomach pouch. The new storage space for caloric content can expand back to original size if the caloric intake exceeds the newly reduced basal metabolic or resting metabolic rate. Thermogenesis is impaired significantly, the ability to consume fruits and vegetables is drastically reduced, and essential nutrients are rationed so that a healthy diet is hard to achieve. This procedure is considered to be a last alternative by the medical community when all other means are exhausted. There are over a hundred thousand of these procedures performed each year on the morbidly obese.
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==Exercise physiology==
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{{Unreferencedsection|date=October 2007}}
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There are several companies testing the public for the respiratory quotient that identifies heart rates attributed to substrate utilization to assist with weight loss. It is theorized that if a person can more accurately know what amount of energy from carbohydrates, fats and proteins is needed to survive, then a person can select consumption patterns to more efficiently match what is required by the body for daily activities. Thus the emphasis shifts from caloric restriction, which slows the BMR or RMR and causes frustration of weight management goals, to substrate utilization, which focuses on what the body needs to stay healthy. By measuring the carbon dioxide expended (''V''CO<sub>2</sub>) in ml/min and dividing that by oxygen consumed ([[VO2_max|''V''O<sub>2</sub>]]) in ml/min you can determine the R.Q., which can then be compared to heart rate for purposes of application. The Balke ''V''O<sub>2</sub> Max running test could help to estimate what cardiac output level could be achieved by a 15 minute level of exertion using the following equation: (((Total distance covered ÷ 15) - 133) × 0.172) + 33.3. For a 50 year old male, weighing 150 pounds (68&nbsp;kg), standing 69¾ inches (177&nbsp;cm), that would be 47 ml/kg/min if he ran 3200 meters in 15 min. However, the same test using gas analysis would reveal more accurate information such as a peak ''V''O<sub>2</sub> of 51.8 ml/kg/min at an anaerobic threshold of 126 beats per minute, at 30.2 ml/kg/min and 58% of ''V''O<sub>2</sub> max. This would be 1725 meters in 15 minutes according to the Balke formula. But only gas analysis could determine the value accurately for purposes of losing weight successfully if that was an objective. So if a person had a measured BMR or RMR of 1610 kcal by gas analysis, and they walked around a track for 10 minutes with a heart rate at 94 beats per minute, they would consume all 25 grams of fat in a single quarter pounder with cheese with a previously determined anaerobic threshold of 126 beats per minute from a Peak ''V''O<sub>2</sub> of 51.8 ml/kg/minute. This analysis is precisely what is lacking from the current regime of dieting programs that stress caloric restriction, total calorie management from scale measure, and RMR or BMR from formulas using height, weight, age, activity level. These methods fail to appreciate the Krebs cycle and the ability of the body to adapt to lifestyle choices through BMR and RMR adjustment. By measuring the body with gas analysis as the principal determinant of BMR under strict fasting conditions, or RMR using less stringent measures, a person who wants to achieve a more optimal level of conditioning is more accurately directed to energy utilization patterns that are effective.
   
==Cardiovascular implications==
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The reason why it's important to understand this difference with exercise testing is because it's essential to take into consideration whether or not the heart is capable of providing exercise stressed muscles with enough oxygen. Conditions such as obesity will affect the ability of formulas to accurately predict external work because the need to move a larger body changes the oxygen cost during exercise at least 5.8 ml/min for each kg of body weight.
   
Heart rate is determined by the [[medulla oblongata]] and part of the [[pons]], two organs located inferior to the hypothalamus on the brain stem. Heart rate is important for basal metabolic rate and resting metabolic rate because it drives the blood supply, stimulating the [[Krebs cycle]]. During exercise that achieves the anaerobic threshold, it is possible to deliver substrates that are desired for optimal energy utilization. The anaerobic threshold is defined as the energy utilization level of heart rate exertion that occurs without oxygen during a standardized test with a specific protocol for accuracy of measurement, such as the Bruce Treadmill protocol. With four to six weeks of targeted training the body systems can adapt to a higher perfusion of mitochondrial density for increased oxygen availability for the Krebs cycle, or tricarboxylic cycle, or the glycolitic cycle. By determining at what point the body switches from anaerobic to aerobic utilization, a direct correlation to how much fat is burned during exercise to the nearest calorie per second is achieved with certain analysers available in health clubs. This in turn leads to a lower resting heart rate, lower blood pressure, and increased resting or basal metabolic rate.
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===Aerobic vs. anaerobic exercise===
   
Knowing what the body burns at rest or through exercise yields (via heart rate monitoring) a targeted program of energy utilization based on metabolic performance. The resting heart rate is correlated to the resting metabolic rate because of the singular contribution made by the heart to survival. By measuring heart rate we can then derive estimations of what level of substrate utilization is actually causing biochemical metabolism in our bodies at rest or in activity. This in turn can help a person to maintain an appropriate level of consumption and utilization by studying a graphical representation of the anaerobic threshold. This can be confirmed by blood tests and gas analysis using either direct or indirect calorimetry to show the effect of substrate utilization. The measures of basal metabolic rate and resting metabolic rate are becoming essential tools for maintaining a healthy body weight.
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Studies published in 1992<ref>{{cite web
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| author=CE Broeder, KA Burrhus, LS Svanevik and JH Wilmore (1992)
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| title=American Journal of Clinical Nutrition
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| work=The effects of aerobic fitness on resting metabolic rate
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| url=http://www.ajcn.org/cgi/content/abstract/55/4/795
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| accessdate=2007-11-23}}</ref> and 1997<ref>{{cite web
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| author=D. A. Smith, J. Dollman, R. T. Withers, M. Brinkman, J. P. Keeves, and D. G. Clark(1997)
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| title=Journal of Applied Physiology
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| work=Relationship between maximum aerobic power and resting metabolic rate in young adult women
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| url=http://jap.physiology.org/cgi/content/abstract/82/1/156
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| accessdate=2007-11-23}}</ref> indicate that the level of aerobic fitness of an individual does not have any correlation with the level of resting metabolism. Both studies find that aerobic fitness levels do not improve the predictive power of Fat Free Mass for resting metabolic rate.
   
==References==
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This suggests that anaerobic exercise may be more effective in raising the resting metabolic rate (Basal Metabolic Rate). [[Anaerobic exercise]], such as [[weight lifting]], builds additional muscle mass, which is Fat Free Mass. Additional Fat Free Mass will lead to a higher resting metabolic rate according to the above studies. Also, while [[aerobic exercise]] is beneficial for cardiovascular reasons as well as direct calorie burning, the above studies indicate it is not useful for increasing resting metabolism.
   
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==Longevity==
  +
In 1926 [[Raymond Pearl]] proposed that [[longevity]] varies inversely with basal metabolic rate (the "rate of living hypothesis"). Support for this hypothesis comes from the fact that mammals with larger body size have longer [[maximum life span]]s and the fact that the longevity of [[Drosophila melanogaster|fruit flies]] varies inversely with ambient [[temperature]].<ref>{{cite journal | author=Miquel J, Lundgren PR, Bensch KG, Atlan H | title=The effects of temperature on the aging process have been investigated in approximately 3500 imagoes of male Drosophila melanogaster | journal=MECHANISMS OF AGING AND DEVELOPMENT | volume=5 | issue=5 | year=1976 | pages=347-370 | id=PMID 823384 }}</ref> Additionally, the life span of houseflies can be extended by preventing physical activity.<ref>{{cite journal | author=Ragland SS, Sohal RS | title=Ambient temperature, physical activity and aging in the housefly, Musca domestica | journal=EXPERIMENTAL GERONTOLOGY | volume=10 | issue=5 | year=1975 | pages=279-289 | id=PMID 1204688 }}</ref>
  +
  +
But the ratio of resting metabolic rate to total daily [[energy]] expenditure can vary between 1.6 to 8.0 between species of [[mammal]]s. Animals also vary in the degree of [[Chemiosmosis|coupling between oxidative phosphorylation and ATP production]], the amount of [[saturated fat]] in mitochondrial [[outer membrane|membrane]]s, the amount of [[DNA repair]], and many other factors that affect maximum life span.<ref>{{cite journal | author=Speakman JR, Selman C, McLaren JS, Harper EJ | title=Living fast, dying when? The link between aging and energetics | journal=THE JOURNAL OF NUTRITION | volume=132 | issue=6, Supplement 2 | year=2002 | pages=1583S-1597S | url=http://jn.nutrition.org/cgi/content/full/132/6/1583S | id=PMID 12042467 }}</ref>
  +
  +
Organism Longevity and Basal Metabolic Rate
  +
  +
In allometric scaling maximum potential life span (MPLS) is directly related to metabolic rate (MR), where MR is the recharge rate of a biomass made up of covalent bonds subject to deterioration over time from thermodynamic, entropic pressure. Metabolism is essentially about redox coupling, and has nothing to do with thermogenesis. Metabolic efficiency (ME) is then expressed as the efficiency of this coupling, a ratio of amperes captured and used by biomass (W), to the amperes available for that purpose. MR is measured in watts, W is measured in grams. These factors are combined in a power law, an elaboration on Kleiber's Law relating MR to W and MPLS, that appears as MR = W^ (4ME-1)/4ME. When ME is 100%, MR = W^3/4, what is known popularly as quarter power scaling, a version of allometric scaling premised upon unreal estimations of biological efficiency.
  +
  +
The equation reveals that as ME drops below 20%, for W < one gram, MR/MPLS increases so dramatically as to endow W with virtual immortality by 16%. The smaller W is to begin with, the more dramatic is the increase in MR as ME diminishes. All of the cells of an organism fit into this range, i.e., less than one gram, and so this MR will be referred to as BMR.
  +
  +
But the equation reveals that as ME increases over 25%, BMR approaches zero. The equation also shows that for all W > one gram, where W is the organization of all of the BMRs of the organism's structure, but also includes the activity of the structure, as ME increases over 25%, MR/MPLS increases rather than decreases, as it does for BMR. An MR made up of an organization of BMRs will be referred to as an FMR. As ME decreases below 25%, FMR diminishes rather than increases as it does for BMR.
  +
  +
The antagonism between FMR and BMR is what marks the process of aging of biomass W in energetic terms. The ME for the organism is the same as that for the cells, such that the success of the organism's ability to find food (and lower its ME), is key to maintaining the BMR of the cells driven, otherwise, by starvation, to approaching zero; while at the same time a lower ME diminishes the FMR/MPLS of the organism.
  +
  +
==Medical considerations==
  +
Each person's metabolism is unique due to their unique physical makeup and physical behavior. For some, this makes weight management a very difficult undertaking requiring sophisticated expertise. There are a number of medical adjustments to natural human processes that can affect one's metabolism.
  +
  +
[[Menopause]] affects metabolism but in different ways for different people, thus hormones are sometimes used to minimize the effects of menopause. [[Weight training]] can have a longer impact on metabolism than [[aerobic exercise|aerobic training]], but there are no formulas currently written which can predict the length and duration of a raised metabolism from trophic changes with anabolic neuromuscular training. [[Gastric bypass surgery]] is used to reduce the content capacity of the stomach, bringing caloric intake down and lowering thermogenesis. Because the surgery significantly reduces caloric consumption, it will decrease BMR and RMR over time in the same fashion as aging, because the volume of the stomach is reduced. The stomach along with the rest of the digestive tract is a major contributor to BMR and RMR. Celiac disease, which reduces the ability of the stomach to digest food, may also reduce BMR and RMR. [[Coeliac disease|Celiac disease]] is fairly common, occurring in 1% of the U.S. population, with 2 million undiagnosed.<ref>{{cite web|url=http://www.nlm.nih.gov/medlineplus/celiacdisease.html|title=MedlinePlus: Celiac Disease|accessdate=2006-09-15}}</ref>{{Fact|date=February 2007}}
  +
  +
==Cardiovascular implications==
  +
Heart rate is determined by the [[medulla oblongata]] and part of the [[pons]], two organs located inferior to the hypothalamus on the brain stem. Heart rate is important for basal metabolic rate and resting metabolic rate because it drives the blood supply, stimulating the Krebs cycle. During exercise that achieves the anaerobic threshold, it is possible to deliver substrates that are desired for optimal energy utilization. The anaerobic threshold is defined as the energy utilization level of heart rate exertion that occurs without oxygen during a standardized test with a specific protocol for accuracy of measurement, such as the Bruce Treadmill protocol (see [[Metabolic equivalent]]). With four to six weeks of targeted training the body systems can adapt to a higher perfusion of mitochondrial density for increased oxygen availability for the Krebs cycle, or tricarboxylic cycle, or the glycolitic cycle. This in turn leads to a lower resting heart rate, lower blood pressure, and increased resting or basal metabolic rate.
  +
  +
Knowing what the body burns at rest or through exercise yields (via heart rate monitoring) a targeted program of energy utilization based on metabolic performance. The resting heart rate is correlated to the resting metabolic rate because of the singular contribution made by the heart to survival. By measuring heart rate we can then derive estimations of what level of substrate utilization is actually causing biochemical metabolism in our bodies at rest or in activity. This in turn can help a person to maintain an appropriate level of consumption and utilization by studying a graphical representation of the anaerobic threshold. This can be confirmed by blood tests and gas analysis using either direct or indirect calorimetry to show the effect of substrate utilization. The measures of basal metabolic rate and resting metabolic rate are becoming essential tools for maintaining a healthy body weight.
  +
  +
==See also==
  +
*[[Metabolic rates]]
  +
  +
==References==
  +
<references/>
  +
* Tsai, Adam Gilden, MD and Wadden, Thomas A. PhD. Systematic Review: An Evaluation of Major Commercial Weightloss Programs in the United States. Ann Intern Med. 2005, 142:56-66.
  +
* Gustafson, Deborah, PhD; Rothenburg, Elisabet, PhD; Blennow, Kaj, PhD; Steen, Bertil, MD,PhD; Skoog, Ingmar, MD, PhD. An 18-Year Follow-Up of Overweight and Risk of Alzheimer Disease. Arch Intern Med: Vol. 163, July 14, 2003, pgs 1524 through 1528.
  +
* Expert Panel on the Identification, Evaluation and Treatment of Overweight in Adults. Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults: Executive Summary. Downloaded from www.ajcn.org on July 9, 2006, Am J Clin Nutr 1998; 68:899-917.
  +
* Segal, Arthur C. A Linear Diet Model. The College Mathematics Journal, January 1987.
  +
* Pike, R.L., and Brown, M. Nutrition: An Integrated Approach, 2nd edition New York: Wiley. 1975
  +
* Sahlin, K., Tonkonogy, and Soderlund, K. Energy Supply and muscle fatigue in humans. Acta Physiol. Scand. 162:261-266. 1998
  +
* Saltin, B, and Gollnick. Skeletal muscle adaptability: Significance for metabolism and performance. In Handbook of Physiology, L.D. Peachey, R.H. Adrian, and S.R. Geiger, eds. Baltimore: Williams & Wilkins. 1983. pg 540 - 555.
  +
* Thorstensson, P. Muscle strength, fiber types and enzymes in man. Acta Physiol. Scand. 102: 443. 1976
  +
* Thorstensson, P. , Sjodin, B. Actinomyosin ATPase, myokinase, CPK and LDH in human fast and slow twitch muscle fibers. Acta Physiol. Scand. 99: 225-229. 1975
  +
* VanHelder, W., Radomski, Goode, R. and Casey, K. Hormonal and metabolic response to three types of exercise of equal duration and external work output. Eur. J. of Appl. Physiol. 54:337-342. 1985
  +
* Wells, J., Balke, B. and Van Fossan, D. Lactic Acid accumulation during work. A suggested standardization of work classification. J Appl. Physiol. 10: 51-55. 1957.
   
 
==See also==
 
==See also==
Line 76: Line 118:
   
 
==External links==
 
==External links==
* [http://www.caloriesperhour.com/faqs_BMR.html ''What do BMR and RMR stand for?'']
+
* [http://www.pubmedcentral.gov/articlerender.fcgi?tool=pubmed&pubmedid=16576330 The original 1918 Harris-Benedict article (free full text)]
* [http://www.code-interactive.com/evolution-diet/healthprofile.html ''Get your BMR'']
+
* [http://chla.library.cornell.edu/cgi/t/text/pageviewer-idx?c=chla;cc=chla;sid=c42d310a7654d488f3e2ae6f21e7be0d;rgn=full%20text;idno=2905932;view=image;seq=0001 Harris-Benedict study. Detailed discusion of antecedents, data, measurements, statistics (Published by The Carnegie Institution of Washington 1919)]
* [http://www.globalrph.com/bee.htm Calculating Basal energy expenditure]
+
* [http://www.caloriesperhour.com/tutorial_BMR.php ''What do BMR and RMR stand for?'']
* [http://health.discovery.com/tools/calculators/basal/basal.html Basal Metabolic Rate Calculator]
+
* [http://health.gov/dietaryguidelines/ Dietary Guidelines from the U.S. Government]
* [http://www.dietandfitnesstoday.com/bmr.php BMR calculator with calorific values of food and exercise]
+
* [http://aic.ucdavis.edu/research1/ProdCouncilCook04.PPT#1 Food Consumption patterns in the U.S.]
  +
* [http://www.unm.edu/~lkravitz/Article%20folder/underbodycomp.html] Body composition Explained
  +
* [http://www.hsph.harvard.edu/nutritionsource/Exercise.htm]Harvard University's explanation of Metabolic Equivalent Tables
  +
* [http://www.ajcn.org/cgi/content/full/71/6/1478] Temporal Trend Shifts and the Ecological Perspectives on Weight Gain in the US
  +
* [http://xnet.kp.org/permanentejournal/sum03/registry.html] Information on the National Weight Control Registry.
  +
* [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=healthus05.chapter.trend-tables] Health Trends in the United States
  +
* [http://www.danoneinstitute.org/objective_nutrition_newsletter/on45.php] BMR as affected by alcohol and nicotine
   
   
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{{enWP|Basal metabolic rate}}
 
{{enWP|Basal metabolic rate}}

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Basal metabolic rate (BMR) is the amount of energy expended while at rest in a neutrally temperate environment, in the post-absorptive state (meaning that the digestive system is inactive, which requires about twelve hours of fasting in humans). The release of energy in this state is sufficient only for the functioning of the vital organs, such as the heart, lungs, brain and the rest of the nervous system, liver, kidneys, sex organs, muscles and skin. BMR decreases with age and with the loss of lean body mass. Increased cardiovascular exercise and muscle mass can increase BMR. Illness, previously consumed food and beverages, environmental temperature, and stress levels can affect one's overall energy expenditure, and can affect one's BMR.

BMR is measured under very restrictive circumstances when a person is awake, but at complete rest. An accurate BMR measurement requires that the person's sympathetic nervous system not be stimulated. A more common and closely related measurement, used under less strict conditions, is resting metabolic rate (RMR).[1]

BMR and RMR are measured by gas analysis through either direct or indirect calorimetry, though a rough estimation can be acquired through an equation using age, sex, height, and weight. Studies of energy metabolism using both methods provide convincing evidence for the validity of the respiratory quotient (R.Q.), which measures the inherent composition and utilization of carbohydrates, fats and proteins as they are converted to energy substrate units that can be used by the body as energy.

Nutrition and dietary considerationsEdit

Basal metabolic rate is usually by far the largest component of total caloric expenditure. However, the Harris-Benedict equations are only approximate and variation in BMR (reflecting varying body composition), in physical activity levels, and in energy expended in thermogenesis make it difficult to estimate the dietary consumption any particular individual needs in order to maintain body weight. 2000 kilocalories is often quoted but is no more than a guideline.

PhysiologyEdit

Both basal metabolic rate and resting metabolic rate are usually expressed in terms of daily rates of energy expenditure. The early work of the scientists J. Arthur Harris and Francis G. Benedict showed that approximate values could be derived using body surface area (computed from height and weight), age, and sex, along with the oxygen and carbon dioxide measures taken from calorimetry. Studies also showed that by eliminating the sex differences that occur with the accumulation of adipose tissue by expressing metabolic rate per unit of "fat-free" or lean body weight, the values between sexes for basal metabolism are essentially the same. Exercise physiology textbooks have tables to show the conversion of height and body surface area as they relate to weight and basal metabolic values.

The primary organ responsible for regulating metabolism is the hypothalamus. The hypothalamus is located on the brain stem and forms the floor and part of the lateral walls of the third ventricle of the cerebrum. The chief functions of the hypothalamus are:

  1. control and integration of activities of the autonomic nervous system (ANS)
    • The ANS regulates contraction of smooth muscle and cardiac muscle, along with secretions of many endocrine organs such as the thyroid gland (associated with many metabolic disorders).
    • Through the ANS, the hypothalamus is the main regulator of visceral activities, such as heart rate, movement of food through the gastrointestinal tract, and contraction of the urinary bladder.
  2. production and regulation of feelings of rage and aggression
  3. regulation of body temperature
  4. regulation of food intake, through two centers:
    • The feeding center or hunger center is responsible for the sensations that cause us to seek food. When sufficient food or substrates have been received and leptin is high, then the satiety center is stimulated and sends impulses that inhibit the feeding center. When insufficient food is present in the stomach and ghrelin levels are high, receptors in the hypothalamus initiate the sense of hunger.
    • The thirst center operates similarly when certain cells in the hypothalamus are stimulated by the rising osmotic pressure of the extracellular fluid. If thirst is satisfied, osmotic pressure decreases.

All of these functions taken together form a survival mechanism that causes us to sustain the body processes that BMR and RMR measure.

BMR estimation formulasEdit

Several prediction equations exist. Historically most notable was Harris-Benedict equation, which was created in 1919.

The original equations from Harris and Benedict are:

  • for men, h = 66.4730+(13.7516\cdot w)+(5.0033\cdot s)-(6.7550\cdot a)
  • for women, h = 655.0955+(9.5634\cdot w)+(1.8496\cdot s)-(4.6756\cdot a)

where h = total heat production per 24 hours at complete rest in kilocalories (kcal), w = weight in kilograms, s = stature (height) in centimeters, and a = age in years, and with the difference in BMR for men and women being mainly due to differences in body weight.[2]

It was the best prediction equation until recently, when MD Mifflin and ST St Jeor in 1990 created new equation:

  • h = (9.99\cdot weight)+(6.25\cdot height)-(4.92\cdot age)+166\cdot sex (1 for males; 0 for females)-161

During the last 100 years, lifestyles have changed and a survey in 2005 showed it to be about 5% more accurate.

Example calculationEdit

For example, a 55 year old woman weighing 130 lb (59 kg) and 5 feet 6 inches (168 cm) tall would have a BMR of 1266 kcal per day or 52.8 kcal/h (61.3 watts). This is computed by as 655 + (9.6 x 59) + (1.8 x 168) - (4.7 x 55).

To calculate Daily Calorie Needs, this BMR value is multiplied by a factor with a value between 1.2 and 1.9, depending on the person's activity level.

An online BMR calculator for both metric and non-metric values can be found at this link [1]

Animal BMREdit

Kleiber's law relates the BMR for animals of different sizes and the observations indicate that the BMR is proportional to the 3/4 power of body mass. Warm blooded, cold blooded and unicellular animals fit on different curves.

BiochemistryEdit

Energy expenditure breakdown
liver 27%
brain 19%
heart 7%
kidneys 10%
skeletal muscle 18%
other organs 19%

About 70% of a human's total energy expenditure is due to the basal life processes within the organs of the body (see table). About 20% of one's energy expenditure comes from physical activity and another 10% from thermogenesis, or digestion of food.[How to reference and link to summary or text] All of these processes require an intake of oxygen along with coenzymes to provide energy for survival (usually from macronutrients like carbohydrates, fats, and proteins) and expel carbon dioxide, which is explained by the Krebs cycle.

What enables the Krebs cycle to perform metabolic changes to fats, carbohydrates, and proteins is energy which can be defined as the ability or capacity to do work. The breakdown of large molecules into smaller molecules associated with release of energy is catabolism. The building up process is termed anabolism. The breakdown of proteins into amino acids is an example of catabolism while the formation of proteins from amino acids is an anabolic process.

Exergonic reactions are energy-releasing reactions and are generally catabolic. Endergonic reactions require energy and include anabolic reactions and the contraction of muscle. Metabolism is the total of all catabolic, exergonic, anabolic, endergonic reactions.

Adenosine Triphosphate (ATP) is the intermediate molecule that drives the exergonic transfer of energy to switch to endergonic anabolic reactions used in muscle contraction. This is what causes muscles to work which can require a breakdown, and also to build in the rest period, which occurs during the strengthening phase associated with muscular contraction. ATP is composed of adenine, a nitrogen containing base, ribose, a five carbon sugar (collectively called adenosine), and three phosphate groups. ATP is a high energy molecule because it stores large amounts of energy in the chemical bonds of the two terminal phosphate groups. The breaking of these chemical bonds in the Krebs Cycle provides the energy needed for muscular contraction.

GlucoseEdit

Because the ratio of hydrogen to oxygen atoms in all carbohydrates is always the same as that in water — that is, 2 to 1 — all of the oxygen consumed by the cells is used to oxidize the carbon in the carbohydrate molecule to form carbon dioxide. Consequently, during the complete oxidation of a glucose molecule, six molecules of carbon dioxide are produced and six molecules of oxygen are consumed.

The overall equation for this reaction is:

C6H12O6 + 6 O2 → 6 CO2 + 6 H2O

Because the gas exchange in this reaction is equal, the respiratory quotient for carbohydrate is unity or 1.0:

R.Q. = 6 CO2 / 6 O2

FatsEdit

The chemical composition for fats differs from that of carbohydrates in that fats contain considerably fewer oxygen atoms in proportion to atoms of carbon and hydrogen. When listed on nutritional information tables, fats are generally divided into six categories: total fats, saturated fatty acid, polyunsaturated fatty acid, monounsaturated fatty acid, dietary cholesterol, and trans fatty acid. From a basal metabolic or resting metabolic perspective, more energy is needed to burn a saturated fatty acid than an unsaturated fatty acid. The fatty acid molecule is broken down and categorized based on the number of carbon atoms in its molecular structure. The chemical equation for metabolism of the twelve to sixteen carbon atoms in a saturated fatty acid molecule shows the difference between metabolism of carbohydrates and fatty acids. Palmitic acid is a commonly studied example of the saturated fatty acid molecule. When palmitic acid is broken down, more oxygen is needed and more carbon dioxide is produced, but the respiratory quotient moves below unity to account for the increased energy required to burn fat molecules (generally nine kilocalories per gram of fat versus four kilocalories for a gram of carbohydrate or protein.)

The overall equation for the substrate utilization of palmitic acid is:

C16H32O2 + 23 O2 → 16 CO2 + 16 H2O

Thus the R.Q. for palmitic acid is 0.696:

R.Q. = 16 CO2 / 23 O2 = 0.696

ProteinsEdit

Proteins are composed of carbon, hydrogen, oxygen, and nitrogen arranged in a variety of ways to form a large combination of amino acids. Unlike fat the body has no storage deposits of protein. All of it is contained in the body as important parts of tissues, blood hormones, and enzymes. The structural components of the body that contain these amino acids are continually undergoing a process of breakdown and replacement. The respiratory quotient for protein metabolism can be demonstrated by the chemical equation for oxidation of albumin:

C72H112N2O22S + 77 O2 → 63 CO2 + 38 H2O + SO3 + 9 CO(NH2)2

The R.Q. for albumin is 63 CO2/ 77 O2 = 0.818

The reason why this is important in the process of understanding protein metabolism is because the body can blend the three macronutrients and based on the mitochondrial density, a preferred ratio can be established which determines how much fuel is utilized in which packets for work accomplished by the muscles. Protein catabolism (breakdown) has been estimated to supply 10% to 15% of the total energy requirement during a two hour training session. However, if a person's muscle glycogen supplies are low from previous exercise sessions, the amount of energy derived from protein catabolism could increase from 15% to 45%. This process could severely degrade the protein structures needed to maintain survival such as contractile properties of proteins in the heart, cellular mitochondria, myoglobin storage, and metabolic enzymes within muscles.

The oxidative system (aerobic) is the primary source of ATP supplied to the body at rest and during low intensity activities and uses primarily carbohydrates and fats as substrates. Protein is not normally metabolized significantly, except during long term starvation and long bouts of exercise (greater than 90 minutes.) At rest approximately 70% of the ATP produced is derived from fats and 30% from carbohydrates. Following the onset of activity, as the intensity of the exercise increases, there is a shift in substrate preference from fats to carbohydrates. During high intensity aerobic exercise, almost 100% of the energy is derived from carbohydrates, if an adequate supply is available.

Exercise physiologyEdit

There are several companies testing the public for the respiratory quotient that identifies heart rates attributed to substrate utilization to assist with weight loss. It is theorized that if a person can more accurately know what amount of energy from carbohydrates, fats and proteins is needed to survive, then a person can select consumption patterns to more efficiently match what is required by the body for daily activities. Thus the emphasis shifts from caloric restriction, which slows the BMR or RMR and causes frustration of weight management goals, to substrate utilization, which focuses on what the body needs to stay healthy. By measuring the carbon dioxide expended (VCO2) in ml/min and dividing that by oxygen consumed (VO2) in ml/min you can determine the R.Q., which can then be compared to heart rate for purposes of application. The Balke VO2 Max running test could help to estimate what cardiac output level could be achieved by a 15 minute level of exertion using the following equation: (((Total distance covered ÷ 15) - 133) × 0.172) + 33.3. For a 50 year old male, weighing 150 pounds (68 kg), standing 69¾ inches (177 cm), that would be 47 ml/kg/min if he ran 3200 meters in 15 min. However, the same test using gas analysis would reveal more accurate information such as a peak VO2 of 51.8 ml/kg/min at an anaerobic threshold of 126 beats per minute, at 30.2 ml/kg/min and 58% of VO2 max. This would be 1725 meters in 15 minutes according to the Balke formula. But only gas analysis could determine the value accurately for purposes of losing weight successfully if that was an objective. So if a person had a measured BMR or RMR of 1610 kcal by gas analysis, and they walked around a track for 10 minutes with a heart rate at 94 beats per minute, they would consume all 25 grams of fat in a single quarter pounder with cheese with a previously determined anaerobic threshold of 126 beats per minute from a Peak VO2 of 51.8 ml/kg/minute. This analysis is precisely what is lacking from the current regime of dieting programs that stress caloric restriction, total calorie management from scale measure, and RMR or BMR from formulas using height, weight, age, activity level. These methods fail to appreciate the Krebs cycle and the ability of the body to adapt to lifestyle choices through BMR and RMR adjustment. By measuring the body with gas analysis as the principal determinant of BMR under strict fasting conditions, or RMR using less stringent measures, a person who wants to achieve a more optimal level of conditioning is more accurately directed to energy utilization patterns that are effective.

The reason why it's important to understand this difference with exercise testing is because it's essential to take into consideration whether or not the heart is capable of providing exercise stressed muscles with enough oxygen. Conditions such as obesity will affect the ability of formulas to accurately predict external work because the need to move a larger body changes the oxygen cost during exercise at least 5.8 ml/min for each kg of body weight.

Aerobic vs. anaerobic exerciseEdit

Studies published in 1992[3] and 1997[4] indicate that the level of aerobic fitness of an individual does not have any correlation with the level of resting metabolism. Both studies find that aerobic fitness levels do not improve the predictive power of Fat Free Mass for resting metabolic rate.

This suggests that anaerobic exercise may be more effective in raising the resting metabolic rate (Basal Metabolic Rate). Anaerobic exercise, such as weight lifting, builds additional muscle mass, which is Fat Free Mass. Additional Fat Free Mass will lead to a higher resting metabolic rate according to the above studies. Also, while aerobic exercise is beneficial for cardiovascular reasons as well as direct calorie burning, the above studies indicate it is not useful for increasing resting metabolism.

LongevityEdit

In 1926 Raymond Pearl proposed that longevity varies inversely with basal metabolic rate (the "rate of living hypothesis"). Support for this hypothesis comes from the fact that mammals with larger body size have longer maximum life spans and the fact that the longevity of fruit flies varies inversely with ambient temperature.[5] Additionally, the life span of houseflies can be extended by preventing physical activity.[6]

But the ratio of resting metabolic rate to total daily energy expenditure can vary between 1.6 to 8.0 between species of mammals. Animals also vary in the degree of coupling between oxidative phosphorylation and ATP production, the amount of saturated fat in mitochondrial membranes, the amount of DNA repair, and many other factors that affect maximum life span.[7]

Organism Longevity and Basal Metabolic Rate

In allometric scaling maximum potential life span (MPLS) is directly related to metabolic rate (MR), where MR is the recharge rate of a biomass made up of covalent bonds subject to deterioration over time from thermodynamic, entropic pressure. Metabolism is essentially about redox coupling, and has nothing to do with thermogenesis. Metabolic efficiency (ME) is then expressed as the efficiency of this coupling, a ratio of amperes captured and used by biomass (W), to the amperes available for that purpose. MR is measured in watts, W is measured in grams. These factors are combined in a power law, an elaboration on Kleiber's Law relating MR to W and MPLS, that appears as MR = W^ (4ME-1)/4ME. When ME is 100%, MR = W^3/4, what is known popularly as quarter power scaling, a version of allometric scaling premised upon unreal estimations of biological efficiency.

The equation reveals that as ME drops below 20%, for W < one gram, MR/MPLS increases so dramatically as to endow W with virtual immortality by 16%. The smaller W is to begin with, the more dramatic is the increase in MR as ME diminishes. All of the cells of an organism fit into this range, i.e., less than one gram, and so this MR will be referred to as BMR.

But the equation reveals that as ME increases over 25%, BMR approaches zero. The equation also shows that for all W > one gram, where W is the organization of all of the BMRs of the organism's structure, but also includes the activity of the structure, as ME increases over 25%, MR/MPLS increases rather than decreases, as it does for BMR. An MR made up of an organization of BMRs will be referred to as an FMR. As ME decreases below 25%, FMR diminishes rather than increases as it does for BMR.

The antagonism between FMR and BMR is what marks the process of aging of biomass W in energetic terms. The ME for the organism is the same as that for the cells, such that the success of the organism's ability to find food (and lower its ME), is key to maintaining the BMR of the cells driven, otherwise, by starvation, to approaching zero; while at the same time a lower ME diminishes the FMR/MPLS of the organism.

Medical considerationsEdit

Each person's metabolism is unique due to their unique physical makeup and physical behavior. For some, this makes weight management a very difficult undertaking requiring sophisticated expertise. There are a number of medical adjustments to natural human processes that can affect one's metabolism.

Menopause affects metabolism but in different ways for different people, thus hormones are sometimes used to minimize the effects of menopause. Weight training can have a longer impact on metabolism than aerobic training, but there are no formulas currently written which can predict the length and duration of a raised metabolism from trophic changes with anabolic neuromuscular training. Gastric bypass surgery is used to reduce the content capacity of the stomach, bringing caloric intake down and lowering thermogenesis. Because the surgery significantly reduces caloric consumption, it will decrease BMR and RMR over time in the same fashion as aging, because the volume of the stomach is reduced. The stomach along with the rest of the digestive tract is a major contributor to BMR and RMR. Celiac disease, which reduces the ability of the stomach to digest food, may also reduce BMR and RMR. Celiac disease is fairly common, occurring in 1% of the U.S. population, with 2 million undiagnosed.[8][How to reference and link to summary or text]

Cardiovascular implicationsEdit

Heart rate is determined by the medulla oblongata and part of the pons, two organs located inferior to the hypothalamus on the brain stem. Heart rate is important for basal metabolic rate and resting metabolic rate because it drives the blood supply, stimulating the Krebs cycle. During exercise that achieves the anaerobic threshold, it is possible to deliver substrates that are desired for optimal energy utilization. The anaerobic threshold is defined as the energy utilization level of heart rate exertion that occurs without oxygen during a standardized test with a specific protocol for accuracy of measurement, such as the Bruce Treadmill protocol (see Metabolic equivalent). With four to six weeks of targeted training the body systems can adapt to a higher perfusion of mitochondrial density for increased oxygen availability for the Krebs cycle, or tricarboxylic cycle, or the glycolitic cycle. This in turn leads to a lower resting heart rate, lower blood pressure, and increased resting or basal metabolic rate.

Knowing what the body burns at rest or through exercise yields (via heart rate monitoring) a targeted program of energy utilization based on metabolic performance. The resting heart rate is correlated to the resting metabolic rate because of the singular contribution made by the heart to survival. By measuring heart rate we can then derive estimations of what level of substrate utilization is actually causing biochemical metabolism in our bodies at rest or in activity. This in turn can help a person to maintain an appropriate level of consumption and utilization by studying a graphical representation of the anaerobic threshold. This can be confirmed by blood tests and gas analysis using either direct or indirect calorimetry to show the effect of substrate utilization. The measures of basal metabolic rate and resting metabolic rate are becoming essential tools for maintaining a healthy body weight.

See alsoEdit

ReferencesEdit

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See alsoEdit

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