Psychology Wiki

Aromatic L-amino acid decarboxylase

34,203pages on
this wiki
Add New Page
Talk0 Share
DOPA decarboxylase (aromatic L-amino acid decarboxylase)
Symbol(s): DDC
Locus: 7 p11
EC number
EntrezGene 1644
OMIM 107930
RefSeq NM_000790
UniProt P20711

Aromatic L-amino acid decarboxylase (EC, synonyms: DOPA decarboxylase, tryptophan decarboxylase, 5-hydroxytryptophan decarboxylase, AAAD) is a lyase enzyme.


It catalyzes several different decarboxylation reactions:

The enzyme uses pyridoxal phosphate as a cofactor.

As a rate limiting stepEdit

In normal dopamine and serotonin (5-HT) neurotransmitter synthesis, AAAD is not the rate-limiting step in either reaction. However, AAAD becomes the rate-limiting step of dopamine synthesis in patients treated with L-DOPA (such as in Parkinson's Disease), and the rate-limiting step of serotonin synthesis in people treated with 5-HTP (such as in mild depression or dysthymia).

AAAD is the rate-limiting enzyme in the formation of biogenic trace amines.

Genetics Edit

The gene encoding the enzyme is located on chromosome 7 in humans.[1]

See alsoEdit

Reference Edit

  1. Lisa J. Scherer, John D. McPherson, John J. Wasmuth and J. Lawrence Marsh (June 1992). Human dopa decarboxylase: Localization to human chromosome 7p11 and characterization of hepatic cDNAs. Genomics 13 (2): 469–471.

External linksEdit


This page uses Creative Commons Licensed content from Wikipedia (view authors).

Ad blocker interference detected!

Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers

Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.

Also on Fandom

Random Wiki