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An anxiogenic substance is one that causes anxiety. Anxiogenic effects can be measured by, for example, the hole-board test in rats and mice.^[1]. Yohimbine is an anxiogenic, used clinically to produce anxiety in experimental subjects.

Anxiolytic substances have the opposite effect: they reduce anxiety.

References

1. ↑ Takeda, H and Tsuji, M and Matsumiya, T (1998). Changes in head-dipping behavior in the hole-board test reflect the anxiogenic and/or anxiolytic state in mice. European Journal of Pharmacology 350 (1): 21–29.

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