Antispasmodic drugs

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For spasmolytics acting on skeletal muscle, see muscle relaxant.

An antispasmodic (synonym: spasmolytic) is a drug that suppresses smooth muscle contraction, especially in tubular organs. The effect is to prevent spasms of the stomach, intestine or urinary bladder.

These include:

• Atropine
• Chlorprothixene
• Meperidine
• Orphenadrine
• Papaverine
• Trihexyphenidyl

Contents 1 other Examples 2 See also 3 References 4 External links

[edit] other Examples

Both dicyclomine and hyoscyamine are antispasmodic due to their anticholinergic action. Both of these drugs have general side effects and can worsen gastroesophageal reflux disease.^[1]

Peppermint oil has been traditionally used as an antispasmodic, and a review of studies on the topic found that it "could be efficacious for symptom relief in IBS"^[2] (as an antispasmodic) although more carefully controlled studies are needed. A later study showed it is an effective antispasmodic when test-applied topically to the intestine during endoscopy.^[3]

The flower Liatris, also called blazing star, has also been used as an antispasmodic. Another old common name for this plant is Colic Root, alluding to its medicinal use as an antispasmodic for the intestines.

[edit] See also

• Anticonvulsive drugs
• Cholinergic blocking drugs
• Muscarinic antagonist
• Muscle relaxing drugs
• Parasympatholytic

[edit] References

1. ↑ Treatment of Irritable Bowel Syndrome - December 15, 2005 -- American Family Physician. URL accessed on 2007-08-14.
2. ↑ Pittler MH, Ernst E (1998). Peppermint oil for irritable bowel syndrome: a critical review and metaanalysis. Am. J. Gastroenterol. 93 (7): 1131-5.
3. ↑ Hiki N, Kurosaka H, Tatsutomi Y, et al (2003). Peppermint oil reduces gastric spasm during upper endoscopy: a randomized, double-blind, double-dummy controlled trial. Gastrointest. Endosc. 57 (4): 475-82.

[edit] External links

• Dictionary at eMedicine Antispasmodic
• MeSH Antispasmodics

v·d·e Urologicals (G04)
Acidifiers	Ammonium chloride, Calcium chloride
Urinary antispasmodics (primarily antimuscarinics)	Darifenacin, Emepronium, Flavoxate, Meladrazine, Oxybutynin, Propiverine, Solifenacin, Terodiline, Tolterodine, Trospium
For erectile dysfunction	Alprostadil, Apomorphine, Moxisylyte, Papaverine, Phentolamine, Yohimbine, PDE5 inhibitors (Avanafil, Sildenafil, Tadalafil, Udenafil, Vardenafil)
Other urologicals	Acetohydroxamic acid, Collagen, Dimethyl sulfoxide, Magnesium hydroxide, Pentosan polysulfate, Phenazopyridine, Phenyl salicylate, Succinimide
For benign prostatic hypertrophy	5α-reductase inhibitors: Dutasteride, Finasteride Alpha blockers: Alfuzosin, Doxazosin, Tamsulosin, Terazosin Herbals: Pygeum africanum, Serenoa repens

This page uses content from the English-language version of Wikipedia. The original article was at Antispasmodics. The list of authors can be seen in the page history. As with Psychology Wiki, the text of Wikipedia is available under the GNU Free Documentation License.