Anisomycin
From Psychology Wiki
Community portal · Tasks to do · News · Help
Clinical · Educational · Ind&Org · Other fields · Professional · Transpersonal · World
Assessment |
Biopsychology |
Comparative |
Cognitive |
Developmental |
Language
Personality |
Philosophy |
Research Methods |
Social |
Statistics
Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology
Anisomycin, also known as Flagecidin (IUPAC name: 3,4-Pyrrolidinediol, 2-[(4-methoxyphenyl)methyl]-, 3-acetate, (2R,3S,4S)-) is an antibiotic produced by Streptomyces griseolus which inhibits protein synthesis. Partial inhibition of DNA synthesis occurs at anisomycin concentrations that effect 95% inhibition of protein synthesis [1]. Anisomycin can activate stress-activated protein kinases, MAP kinase and other signal transduction pathways.
Anisomycin is inactive against bacteria.
Contents |
[edit] Pharmacology
Anisomycin interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
Anisomycin is also mentioned as a potential psychiatric drug, as it may erase "short-range memory" [2].
Injection of anisomycin into the hippocampus has been proposed for selective removal of memories [3].
[edit] References
- 1.
Inhibitors of protein biosynthesis. II. Mode of action of anisomycin. 1967 Jul 10; PMID 6027796 Free text (PDF - 990K)
- 2. Memory for context is impaired by injecting anisomycin into dorsal hippocampus following context exploration. 2002 Aug 21; PMID 12191817
- 3. Consolidation and reconsolidation of incentive learning in the amygdala. ; PMID 15673662 Free text
[edit] See also
[edit] External links
| This page uses content from the English-language version of Wikipedia. The original article was at Anisomycin. The list of authors can be seen in the page history. As with Psychology Wiki, the text of Wikipedia is available under the GNU Free Documentation License. |
