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The structure of Anisomycin

Anisomycin, also known as Flagecidin (IUPAC name: 3,4-Pyrrolidinediol, 2-[(4-methoxyphenyl)methyl]-, 3-acetate, (2R,3S,4S)-) is an antibiotic produced by Streptomyces griseolus which inhibits protein synthesis. Partial inhibition of DNA synthesis occurs at anisomycin concentrations that effect 95% inhibition of protein synthesis [1]. Anisomycin can activate stress-activated protein kinases, MAP kinase and other signal transduction pathways.

Anisomycin is inactive against bacteria.


Anisomycin interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.

Anisomycin is also mentioned as a potential psychiatric drug, as it may erase "short-range memory" [2].

Injection of anisomycin into the hippocampus has been proposed for selective removal of memories [3].


1. Free text Inhibitors of protein biosynthesis. II. Mode of action of anisomycin. 1967 Jul 10; PMID 6027796 Free text (PDF - 990K)
2. Memory for context is impaired by injecting anisomycin into dorsal hippocampus following context exploration. 2002 Aug 21; PMID 12191817
3. Free text Consolidation and reconsolidation of incentive learning in the amygdala. ; PMID 15673662 Free text

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