Angiotensin-converting enzyme
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| Angiotensin I converting enzyme | |
|---|---|
| Symbol(s): | ACE CD143, CD143 |
| Locus: | 17 q23 |
| EC number | 3.4.15.1 |
| EntrezGene | 1636 |
| OMIM | 106180 |
| RefSeq | NM_000789 |
| UniProt | P12821 |
Angiotensin I converting enzyme (ACE, EC 3.4.15.1) is an exopeptidase.
Contents |
[edit] Functions
It has two primary functions:
- it catalyses the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. [1]
- it is involved in the inactivation of bradykinin, a potent vasodilator.
These two actions of ACE make it an ideal target in the treatment of conditions such as high blood pressure, heart failure, diabetic nephropathy and type 2 diabetes mellitus. Inhibition of ACE (by ACE inhibitors) results in decreased formation of Angiotensin II (a far more potent vasoconstrictor than Angiotensin I) and decreased inactivation of bradykinin.
[edit] Synonyms
ACE is also known as:
- peptidyl dipeptidase A
- carboxycathepsin
- kininase II (kinin-kallikrein system)
- CD 143
- ACE1
[edit] Genetics
The ACE gene, ACE, encodes 2 isozymes. The somatic isozyme is expressed in many tissues, including vascular endothelial cells, epithelial kidney cells, and testicular Leydig cells, whereas the germinal is expressed only in sperm.
[edit] See also
[edit] References
[edit] External links
Proteins: clusters of differentiation (see also list of human clusters of differentiation) | |
|---|---|
| 1-50 | CD1 (CD1a-c, CD1d) - CD2 - CD3 - CD4 - CD5 - CD8 - CD9 - CD10 - CD11 (CD11a, CD11b, CD11c) - CD13 - CD14 - CD15 - CD16 - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 - CD33 - CD34 - CD35 - CD36 - CD37 -CD38 - CD40 - CD43 - CD44 - CD45 - CD46 - CD49 (CD49a, CD49b, CD49c, CD49d) |
| 51-100 | CD52 - CD53 - CD54 - CD55 - CD56 - CD58 - CD59 - CD61 - CD62 (CD62E, CD62L, CD62P) - CD63 - CD64 - CD66e - CD68 - CD70 - CD71 - CD72 - CD79 - CD80 - CD81 - CD82 - CD86 - CD88 - CD89 - CD90 - CD94 - CD95 - CD98 |
| 101-350 | CD103 - CD106 - CD114 - CD116 - CD117 - CD118 - CD120 - CD122 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD137 - CD138 - CD141 - CD142 - CD143 - CD146 - CD147 - CD151 - CD152 - CD153 - CD154 - CD155 - CD162 - CD164 - CD169 - CD184 - CD206 - CD209 - CD257 - CD278 - CD281 - CD282 - CD283 - CD304 |
Hydrolase: proteases (EC 3.4) | |
|---|---|
| Exopeptidase 3.4.11-19 | Angiotensin-converting enzyme - Dipeptidase - Dipeptidyl peptidase-4 - DD-transpeptidase Metalloexopeptidases: Aminopeptidase (Alanine, Cystinyl, Leucyl, Glutamyl) - Carboxypeptidase (A, B, C, E, Glutamate II) |
| Endopeptidase 3.4.21-24 | Serine proteases - Cysteine protease - Aspartic acid protease - Metalloendopeptidases |
| Cathepsin 3.4.18,21,22,23 | A - B - C - K |
| This page uses content from the English-language version of Wikipedia. The original article was at Angiotensin-converting enzyme. The list of authors can be seen in the page history. As with Psychology Wiki, the text of Wikipedia is available under the GNU Free Documentation License. |
