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Amyloidosis

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Small bowel duodenum with amyloid deposition congo red 10X.jpg|
Amyloidosis
ICD-10 E85
ICD-9 277.3
OMIM [1]
DiseasesDB 633
MedlinePlus [2]
eMedicine med/3377 med/3888
MeSH {{{MeshNumber}}}


In medicine, amyloidosis refers to a variety of conditions in which amyloid proteins are abnormally deposited in organs and/or tissues, causing disease. A protein is amyloid if, due to an alteration in its secondary structure, it takes on a particular insoluble form, called the beta-pleated sheet.

Approximately 25 different proteins are known that can form amyloid in humans, most of them are constituents of the plasma.

Different amyloidoses can be systemic (affecting many different organ systems) or organ-specific. Some are inherited, due to mutations in the precursor protein. Other, secondary forms are due to different diseases causing overabundant or abnormal protein production-such as with over production of immunoglobulin light chains in multiple myeloma (termed AL amyloid), or with continuous overproduction of acute phase proteins in chronic inflammation (which can lead to AA amyloid).


DiagnosisEdit

Amyloid can be diagnosed on histological examination of affected tissue. Amyloid deposits can be identified histologically by Congo red staining and viewing under polarized light where amyloid deposits produce a distinctive 'apple green birefringence'. Further, specific, tests are available to more precisely identify the amyloid protein. Biopsies are taken from affected organs (for example, the kidney), or often in the case of systemic amyloid, from the rectum or anterior abdominal adipose tissue. In addition, all amyloid deposits contain serum amyloid P component (SAP), a circulating protein of the pentraxin family. Radionuclide SAP scans have been developed which can anatomically localize amyloid deposits in patients.


Systemic amyloidosis Edit

Primary/Hereditary amyloidosisEdit

These rare hereditary disorders are usually due to point mutations in precursor proteins, and are also usually autosomal dominantly transmitted.The precursor proteins are;

Secondary amyloidosisEdit

These are far more common than the primary amyloidoses.

Organ-specific amyloidosis Edit

In almost all of the organ-specific pathologies, there is significant debate as to whether the amyloid plaques are the causal agent of the disease or instead a downstream consequence of a common idiopathic agent. The associated proteins are indicated in parentheses.

Neurological amyloid

Cardiovascular amyloid

Other

Famous people to have this disease include James Oliver Rigney, Jr., better known as Robert Jordan, who was diagnosed with primary amyloidosis with cardiomyopathy (cardiac amyloidosis). He later died before finishing the 12th and final book in his Wheel of Time book series.

ReferencesEdit


External linksEdit

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