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Amoxapine chemical structure

IUPAC name
CAS number
ATC code


Chemical formula {{{chemical_formula}}}
Molecular weight 313.781
Bioavailability  ?
Metabolism Hepatic (cytochrome P450 system)
Elimination half-life 8-10 hours (30 hours for major metabolites)
Excretion Renal
Pregnancy category {{{pregnancy_category}}}
Legal status {{{legal_status}}}
Routes of administration Oral

Amoxapine (brand-names Asendin®, Asendis®, Defanyl®, Demolox®, Moxadil®) is a tetracyclic antidepressant of the dibenzoxazepine class. It is used in the treatment of depression, panic disorders and bipolar disorder.

Amoxapine is a strong reuptake inhibitor of norepinephrine and weak reuptake inhibitor of serotonin. One of its major metabolites, 7-hydroxyamoxapine, has a dopamine receptor blocking effect.


  • Mosby Year-Book, Inc. (1995). Physician's GenRx: The Complete Drug Reference (5th Ed.). Riverside, CT: Denniston Publishing Co.
  • Palfai, T. & Jankiewicz, H. (1997). Drugs and Human Behavior (2nd Ed.). Madison, WI: Brown & Benchmark.
  • Hedges, D. & Burchfield, C. (2006). Mind, Brain, and Drug: An Introduction to Psychopharmacology. Boston, MA: Pearson.

Antidepressants (ATC N06A) edit
Monoamine oxidase inhibitors (MAOI) Harmaline, Iproclozide, Iproniazid, Isocarboxazid, Nialamide, Phenelzine, Selegiline, Toloxatone, Tranylcypromine
Reversible inhibitor of monoamine oxidase A (RIMA) Brofaromine, Moclobemide
Dopamine reuptake inhibitor (DARI) Amineptine, Phenmetrazine, Vanoxerine, Modafinil
Norepinephrine-dopamine reuptake inhibitors Bupropion
Norepinephrine reuptake inhibitor (NRI) or (NARI) Atomoxetine, Maprotiline, Reboxetine, Viloxazine
Serotonin-norepinephrine reuptake inhibitor (SNRI) Duloxetine, Milnacipran, Venlafaxine
Selective serotonin reuptake inhibitor (SSRI) Alaproclate, Etoperidone, Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Zimelidine
Selective serotonin reuptake enhancer (SSRE) Tianeptine
Tricyclic antidepressants (TCA) Amitriptyline, Amoxapine, Butriptyline, Clomipramine, Desipramine, Dibenzepin, Dothiepin, Doxepin, Imipramine, Iprindole, Lofepramine, Melitracen, Nortriptyline, Opipramol, Protriptyline, Trimipramine
Tetracyclic antidepressants Maprotiline, Mianserin, Nefazodone, Trazodone
Noradrenergic and specific serotonergic antidepressant (NaSSA) Mirtazapine

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