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Amisulpride
4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]- 5-ethylsulfonyl-2-methoxy-benzamide IUPAC name
CAS number 53583-79-2	ATC code N05AL05
PubChem 2159	DrugBank none
Chemical formula	{{{chemical_formula}}}
Molecular weight	369.48 g/mol
Bioavailability	48%[2]
Metabolism	?
Elimination half-life	12 h[2]
Excretion	Renal[2]
Pregnancy category	{{{pregnancy_category}}}
Legal status	Rx-only
Routes of administration	Oral, intramuscular[1]

Amisulpride (brand-name Solian®) is an antipsychotic drug sold by Sanofi-Aventis. Amisulpride is a selective dopamine antagonist. It has a high affinity for D2 (Ki 2.8 nM) and D3 (Ki 3.2 nM) dopaminergic receptors. Its dosage ranges from 200 to 1200 mg/day. Lower doses (less than 50 mg) preferentially block d2 autoreceptors that control the synthesis and release of dopamine. This results in an increase in dopaminergic transmission. This dopamine increase is hypothesized to cause a reduction in both depressive and negative symptoms. Higher doses of the drug block the postsynaptic dopamine receptors resulting in an improvement in psychoses. Amisulpride is not approved by the Food and Drug Administration for use in the United States. Amisulpride (in 50mg doses) is marketed as a treatment for dysthymia in Italy (as Deniban) In one study, anxiety measured by HAM-A total mean score decreased significantly more with amisulpride 50mg/day (63%) than with fluoxetine 20mg/day (54%; P = 0.021).^[3]

[edit] Side effects

Prolactin induction, nausea, weight gain, although much less than similar drugs in its class, and less commonly QT interval prolongation (which can lead to serious heart arrhythmias). Overdoses of amisulpride have been linked with torsades de pointes.^[4]

[edit] See also

• Sulpiride
• Sultopride
• Antipsychotic
• Dopamine hypothesis of psychosis

[edit] References

This box: view • talk • edit Psycholeptics: antipsychotics (N05A)
Phenothiazine typical antipsychotics	Chlorpromazine • Fluphenazine • Mesoridazine • Perphenazine • Prochlorperazine • Promazine • Thioridazine/Sulforidazine • Trifluoperazine
Other typical antipsychotics	Indoles (Molindone) • Butyrophenones (Azaperone, Benperidol, Droperidol, Haloperidol) • Thioxanthenes (Flupentixol, Chlorprothixene, Thiothixene, Zuclopenthixol) • diphenylbutylpiperidines (Fluspirilene, Penfluridol, Pimozide) • other (Loxapine)
Atypical antipsychotics	Butyrophenones (Melperone) • Indoles (Sertindole, Ziprasidone) • Benzamides (Sulpiride, Remoxipride, Amisulpride) • diazepines/oxazepines/thiazepines (Clozapine, Olanzapine, Quetiapine) • other (Aripiprazole, Risperidone, Paliperidone, Zotepine)

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This page uses content from the English-language version of Wikipedia. The original article was at Amisulpride. The list of authors can be seen in the page history. As with Psychology Wiki, the text of Wikipedia is available under the GNU Free Documentation License.