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(Created page with "{{CogPsy}} In Alzheimer’s disease and olfaction can be impaired. Indeed this is so characteristic that Solomon et al (1998) <ref>Solomon, Gary S.; Petrie, William M. ...")
 
 
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In [[Alzheimer’s disease]] and [[olfaction]] can be impaired. Indeed this is so characteristic that Solomon et al (1998) <ref>Solomon, Gary S.; Petrie, William M. Hart, James ; Brackin, Henry B. Jr. (1998). Olfactory Dysfunction Discriminates Alzheimer's Dementia From Major Depression. The Journal of Neuropsychiatry and Clinical Neurosciences ;10:64-67.</ref> suggested that the [[Pocket Smell Test]] could be used as a diagnostic tool to distinguish between the condition and [[major depression]].
 
In [[Alzheimer’s disease]] and [[olfaction]] can be impaired. Indeed this is so characteristic that Solomon et al (1998) <ref>Solomon, Gary S.; Petrie, William M. Hart, James ; Brackin, Henry B. Jr. (1998). Olfactory Dysfunction Discriminates Alzheimer's Dementia From Major Depression. The Journal of Neuropsychiatry and Clinical Neurosciences ;10:64-67.</ref> suggested that the [[Pocket Smell Test]] could be used as a diagnostic tool to distinguish between the condition and [[major depression]].
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==[[Hyposmia]] - decreased ability to smell==
 
Doty<ref>Doty RL: Olfactory dysfunction in neurodegenerative disorders, in Smell and Taste in Health and Disease, edited by Getchell TV. New York, Raven, 1991, pp 735—751</ref> reviewed 13 studies investigating olfaction in Alzheimer's patients compared to age-matched controls and identified that the majority of studies found significantly decreased function in Alzheimer's patients.
 
Doty<ref>Doty RL: Olfactory dysfunction in neurodegenerative disorders, in Smell and Taste in Health and Disease, edited by Getchell TV. New York, Raven, 1991, pp 735—751</ref> reviewed 13 studies investigating olfaction in Alzheimer's patients compared to age-matched controls and identified that the majority of studies found significantly decreased function in Alzheimer's patients.
   
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Morgan et al.<ref>Morgan CD, Nordin S, Murphy C: Odor identification as an early marker for Alzheimer's disease: impact of lexical functioning and detection sensitivity. J Clin Exp Neuropsychol 1995; 17:793—803</ref> reported that odor identification tasks could be useful in diagnosing Alzheimer's and that possible language deficits in this group were not responsible for the difficulties in smell identification.
 
Morgan et al.<ref>Morgan CD, Nordin S, Murphy C: Odor identification as an early marker for Alzheimer's disease: impact of lexical functioning and detection sensitivity. J Clin Exp Neuropsychol 1995; 17:793—803</ref> reported that odor identification tasks could be useful in diagnosing Alzheimer's and that possible language deficits in this group were not responsible for the difficulties in smell identification.
   
 
 
 
==[[Hyposmia]] - decreased ability to smell==
 
   
 
==[[Anosmia]] - lack of ability to smell==
 
==[[Anosmia]] - lack of ability to smell==
For some people wih Alzeimers the sense of smell can disappear completely.<ref>Solomon GS: Anosmia in Alzheimer's disease. Percept Mot Skills 1994; 79:1249—1250,/ref>
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For some people wih Alzeimers the sense of smell can disappear completely.<ref>Solomon GS (1994). Anosmia in Alzheimer's disease. Percept Mot Skills ; 79:1249—1250,</ref>
   
   

Latest revision as of 07:53, November 25, 2011

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In Alzheimer’s disease and olfaction can be impaired. Indeed this is so characteristic that Solomon et al (1998) [1] suggested that the Pocket Smell Test could be used as a diagnostic tool to distinguish between the condition and major depression.


Hyposmia - decreased ability to smellEdit

Doty[2] reviewed 13 studies investigating olfaction in Alzheimer's patients compared to age-matched controls and identified that the majority of studies found significantly decreased function in Alzheimer's patients.

Nordin and Murphy[3] also documented impaired olfaction in patients with possible Alzheimer's.

Morgan et al.[4] reported that odor identification tasks could be useful in diagnosing Alzheimer's and that possible language deficits in this group were not responsible for the difficulties in smell identification.


Anosmia - lack of ability to smellEdit

For some people wih Alzeimers the sense of smell can disappear completely.[5]


NeuroscienceEdit

A postmortem study by Reyes et al (1993) [6] has demonstrated increased numbers of neurofibrillary tangles and neuritic plaques in the olfactory cortex of Alzheimer's patients versus age-matched control subjects. Doty[7] has suggested that the magnitude of the olfactory deficit parallels the progression and severity of the Alzheimer's process.


ReferencesEdit

  1. Solomon, Gary S.; Petrie, William M. Hart, James ; Brackin, Henry B. Jr. (1998). Olfactory Dysfunction Discriminates Alzheimer's Dementia From Major Depression. The Journal of Neuropsychiatry and Clinical Neurosciences ;10:64-67.
  2. Doty RL: Olfactory dysfunction in neurodegenerative disorders, in Smell and Taste in Health and Disease, edited by Getchell TV. New York, Raven, 1991, pp 735—751
  3. Nordin S, Murphy C: Impaired sensory and cognitive olfactory function in questionable Alzheimer's disease. Neuropsychology 1996; 10:113—119
  4. Morgan CD, Nordin S, Murphy C: Odor identification as an early marker for Alzheimer's disease: impact of lexical functioning and detection sensitivity. J Clin Exp Neuropsychol 1995; 17:793—803
  5. Solomon GS (1994). Anosmia in Alzheimer's disease. Percept Mot Skills ; 79:1249—1250,
  6. Reyes PF, Deems DA, Suarez MG: (1993). Olfactory-related changes in Alzheimer's disease: a quantitative neuropathological study. Brain Research Bulletin  ; 32:1—5
[[category:Olfactory perception]

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