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In [[Alzheimer’s disease]] and [[olfaction]] can be impaired. Indeed this is so characteristic that Solomon et al (1998) <ref>Solomon, Gary S.; Petrie, William M. Hart, James ; Brackin, Henry B. Jr. (1998). Olfactory Dysfunction Discriminates Alzheimer's Dementia From Major Depression. The Journal of Neuropsychiatry and Clinical Neurosciences ;10:64-67.</ref> suggested that the [[Pocket Smell Test]] could be used as a diagnostic tool to distinguish between the condition and [[major depression]]. |
In [[Alzheimer’s disease]] and [[olfaction]] can be impaired. Indeed this is so characteristic that Solomon et al (1998) <ref>Solomon, Gary S.; Petrie, William M. Hart, James ; Brackin, Henry B. Jr. (1998). Olfactory Dysfunction Discriminates Alzheimer's Dementia From Major Depression. The Journal of Neuropsychiatry and Clinical Neurosciences ;10:64-67.</ref> suggested that the [[Pocket Smell Test]] could be used as a diagnostic tool to distinguish between the condition and [[major depression]]. |
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Doty<ref>Doty RL: Olfactory dysfunction in neurodegenerative disorders, in Smell and Taste in Health and Disease, edited by Getchell TV. New York, Raven, 1991, pp 735—751</ref> reviewed 13 studies investigating olfaction in Alzheimer's patients compared to age-matched controls and identified that the majority of studies found significantly decreased function in Alzheimer's patients. |
Doty<ref>Doty RL: Olfactory dysfunction in neurodegenerative disorders, in Smell and Taste in Health and Disease, edited by Getchell TV. New York, Raven, 1991, pp 735—751</ref> reviewed 13 studies investigating olfaction in Alzheimer's patients compared to age-matched controls and identified that the majority of studies found significantly decreased function in Alzheimer's patients. |
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Morgan et al.<ref>Morgan CD, Nordin S, Murphy C: Odor identification as an early marker for Alzheimer's disease: impact of lexical functioning and detection sensitivity. J Clin Exp Neuropsychol 1995; 17:793—803</ref> reported that odor identification tasks could be useful in diagnosing Alzheimer's and that possible language deficits in this group were not responsible for the difficulties in smell identification. |
Morgan et al.<ref>Morgan CD, Nordin S, Murphy C: Odor identification as an early marker for Alzheimer's disease: impact of lexical functioning and detection sensitivity. J Clin Exp Neuropsychol 1995; 17:793—803</ref> reported that odor identification tasks could be useful in diagnosing Alzheimer's and that possible language deficits in this group were not responsible for the difficulties in smell identification. |
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==[[Anosmia]] - lack of ability to smell== |
==[[Anosmia]] - lack of ability to smell== |
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| − | For some people wih Alzeimers the sense of smell can disappear completely.<ref>Solomon GS |
+ | For some people wih Alzeimers the sense of smell can disappear completely.<ref>Solomon GS (1994). Anosmia in Alzheimer's disease. Percept Mot Skills ; 79:1249—1250,</ref> |
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In Alzheimer’s disease and olfaction can be impaired. Indeed this is so characteristic that Solomon et al (1998) [1] suggested that the Pocket Smell Test could be used as a diagnostic tool to distinguish between the condition and major depression.
Hyposmia - decreased ability to smell
Doty[2] reviewed 13 studies investigating olfaction in Alzheimer's patients compared to age-matched controls and identified that the majority of studies found significantly decreased function in Alzheimer's patients.
Nordin and Murphy[3] also documented impaired olfaction in patients with possible Alzheimer's.
Morgan et al.[4] reported that odor identification tasks could be useful in diagnosing Alzheimer's and that possible language deficits in this group were not responsible for the difficulties in smell identification.
Anosmia - lack of ability to smell
For some people wih Alzeimers the sense of smell can disappear completely.[5]
Neuroscience
A postmortem study by Reyes et al (1993) [6] has demonstrated increased numbers of neurofibrillary tangles and neuritic plaques in the olfactory cortex of Alzheimer's patients versus age-matched control subjects. DotyCite error: Invalid <ref> tag; refs with no name must have content has suggested that the magnitude of the olfactory deficit parallels the progression and severity of the Alzheimer's process.
References
- ↑ Solomon, Gary S.; Petrie, William M. Hart, James ; Brackin, Henry B. Jr. (1998). Olfactory Dysfunction Discriminates Alzheimer's Dementia From Major Depression. The Journal of Neuropsychiatry and Clinical Neurosciences ;10:64-67.
- ↑ Doty RL: Olfactory dysfunction in neurodegenerative disorders, in Smell and Taste in Health and Disease, edited by Getchell TV. New York, Raven, 1991, pp 735—751
- ↑ Nordin S, Murphy C: Impaired sensory and cognitive olfactory function in questionable Alzheimer's disease. Neuropsychology 1996; 10:113—119
- ↑ Morgan CD, Nordin S, Murphy C: Odor identification as an early marker for Alzheimer's disease: impact of lexical functioning and detection sensitivity. J Clin Exp Neuropsychol 1995; 17:793—803
- ↑ Solomon GS (1994). Anosmia in Alzheimer's disease. Percept Mot Skills ; 79:1249—1250,
- ↑ Reyes PF, Deems DA, Suarez MG: (1993). Olfactory-related changes in Alzheimer's disease: a quantitative neuropathological study. Brain Research Bulletin ; 32:1—5
[[category:Olfactory perception]