Individual differences |
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Alpha methylparatyrosine chemical structure
| 2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid|
| CAS number |
| ATC code |
| PubChem |
| DrugBank |
|Molecular weight||195.215 g/mol|
|Routes of administration|
AMPT administration leads to a transient exacerbation of depressive symptoms in patients that have responded to catecholaminergic antidepressants. The mood changes induced by AMPT may be mediated by decreases in norepinephrine, while changes in selective attention and motivation may be mediated by dopamine.
As a competitive inhibitor of tyrosine hydroxylase, it prevents the conversion of tyrosine to L-DOPA, the precursor to dopamine. This results in lowered systematic catecholamine (dopamine, epinephrine and norepinephrine) levels.
References & Bibliography
- ↑ Ankenman R, Salvatore MF (2007). Low dose alpha-methyl-para-tyrosine (AMPT) in the treatment of dystonia and dyskinesia. J Neuropsychiatry Clin Neurosci 19 (1): 65–9.
- ↑ Use of α-methyl-p-tyrosine to inhibit melanin production in iris melanocytes
- ↑ Zimmermann RC, Krahn LE, Klee GG, Ditkoff EC, Ory SJ, Sauer MV (2001). Prolonged inhibition of presynaptic catecholamine synthesis with alpha-methyl-para-tyrosine attenuates the circadian rhythm of human TSH secretion. J. Soc. Gynecol. Investig. 8 (3): 174–8.
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