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Ephedrine

Chemical structure of ephedrine, a phenethylamine alkaloid

An alkaloid is, strictly speaking, a naturally occurring amine produced by a plant,[1] but amines produced by animals and fungi are also called alkaloids. Many alkaloids have pharmacological effects on humans and other animals.

The name derives from the word alkaline; originally, the term was used to describe any nitrogen-containing base. Alkaloids are usually derivatives of amino acids, and many have a bitter taste. They are found as secondary metabolites in plants (e.g. potatoes and tomatoes), animals (e.g. shellfish) and fungi. Many alkaloids can be purified from crude extracts by acid-base extraction.

While many alkaloids are poisonous, some are used medicinally as analgesics (pain relievers) or anaesthetics, particularly morphine and codeine, and for other uses.

Alkaloid classifications Edit

Alkaloids are usually classified by their common molecular feat, based on the metabolic pathway used to construct the molecule. When not much was known about the biosynthesis of alkaloids, they were grouped under the names of known compounds, even some non-nitrogenous ones (since those molecules' structures appear in the finished product; the opium alkaloids are sometimes called "phenanthrenes", for example), or by the plants or animals they were isolated from. When more is learned about a certain alkaloid, the grouping is changed to reflect the new knowledge, usually taking the name of a biologically-important amine that stands out in the synthesis process.

  • Vinca alkaloids: vinblastine, vincristine. They are antineoplastic and binds free tubulin dimers thereby disrupting balance between microtuble polymerization and delpolymerization resulting in arrest of cells in metaphase.

Physicochemical Properties of Alkaloids Edit

  • Molecular weight 100-900
  • Those without oxygen atoms in the structure are usually liquid at ordinary temperature (e.g. nicotine, sparteine, coniine)
  • Those with oxygen atoms are crystalline (e.g. berberine)
  • Optically active
  • Basicity depends on the availability of lone pairs of electrons on the N atom & the type of heterocycle and substituents.
  • Ability to form salts with mineral acids (e.g. with HCl, H2SO4, HNO3) or organic acids (e.g. tartrates, sulfamates, maleates)

See alsoEdit

References & BibliographyEdit

  1. Carey, Francis A. [1987] (2006). Organic Chemistry, 6th ed., 954, New York: McGraw Hill. ISBN 0-07-282837-4. "(Strictly speaking, these compounds are not classified as alkaloids because they are not isolated from plants.)"

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