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Aldolase A

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Assessment | Biopsychology | Comparative | Cognitive | Developmental | Language | Individual differences | Personality | Philosophy | Social |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |

Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)


Aldolase A
300px
Enzyme Fructose 1,6-bisphosphate aldolase
PDB Code PDB 4ALD
Organism Human
Tissue Muscle
Complexed molecules fructose 1,6-bisphosphate

Aldolase A is an enzyme which catalyses one of the aldol reactions: The substrate, fructose 1,6-bisphosphate (F-1,6-BP) is broken down into glyceraldehyde 3-phosphate and dihydroxyacetone phosphate (DHAP). This reaction is a part of glycolysis.

β-D-fructose 1,6-phosphate fructose bisphosphate aldolase D-glyceraldehyde 3-phosphate dihydroxyacetone phosphate
Beta-D-fructose-1,6-bisphosphate wpmp D-glyceraldehyde-3-phosphate wpmp + Glycerone-phosphate wpmp
Biochem reaction arrow reversible NNNN horiz med
fructose bisphosphate aldolase

Compound C05378 at KEGG Pathway Database.

Enzyme 4.1.2.13 at KEGG Pathway Database.
Compound C00111 at KEGG Pathway Database.
Compound C00118 at KEGG Pathway Database.


The numbering of the carbon atoms indicates the fate of the carbons according to their position in fructose 6-phosphate.

MechanismEdit

In mammalian aldolase the key catylitic amino acid residues involved in the reaction are lysine and tyrosine. The tyrosine acts as an efficient hydrogen acceptor while the lysine covalently binds and stabilizes the intermediates. Many bacteria use two magnesium ions in place of the lysine.

ALDO reaction
The reaction mechanism of aldolase.
The enzyme's reactive site amino acid's side chains are shown in blue.
Abbreviations: DHAP - dihydroxyacetone phosphate; Fru1,6bP - Fructose-1,6-bisphosphate; GAD - glyceraldehyde 3-phosphate;
Dr Joe KiffAdded by Dr Joe Kiff

External linksEdit

Glucose wpmp This metabolism related enzyme article is a stub. You can help Wikipedia by expanding it

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