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The adverse psychological reaction to prescription drugs is a particular form of adverse drug reaction associated with prescription drugs some of them psychiatric medications others prescribed for a wide variety of physical disorders.

The reactions produce cognitive deficits of varying degrees of difficulty and inconvenience. Because some of these reactions are subtle, and people compensate for them, they are sometimes ignored. Most research has focused on the gross effects of psychiatric side effects and often drug trials do not assess these less clearcut consequences.

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