Wikia

Psychology Wiki

Adrafinil

Talk0
34,142pages on
this wiki
Revision as of 21:58, February 6, 2010 by Dr Joe Kiff (Talk | contribs)

Assessment | Biopsychology | Comparative | Cognitive | Developmental | Language | Individual differences | Personality | Philosophy | Social |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |

Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)


Adrafinil chemical structure
Adrafinil

2-benzhydrylsulfinylethanehydroxamic acid
IUPAC name
CAS number
63547-13-7
ATC code

N06BX17

PubChem
3033226
DrugBank
[1]
Chemical formula
Molecular weight 289.351 g/mol
Bioavailability
Metabolism
Elimination half-life
Excretion
Pregnancy category
Legal status
Routes of administration Oral

Adrafinil is a mild central nervous system stimulant drug used to relieve excessive sleepiness and inattention in elderly patients. It is also used off-label by individuals wishing to avoid fatigue, such as night workers or others who need to stay awake and alert for long periods of time.

Adrafinil is a prodrug; it is primarily metabolized in vivo to modafinil (Provigil®), resulting in nearly identical pharmacologic effects. Unlike modafinil, however, it takes time for the metabolite to accumulate to active levels in the bloodstream. Effects usually are apparent within 45-60 minutes when taken orally on an empty stomach.

Adrafinil, also known by the codename CRL 40028, has as its chemical name 2-(Diphenylmethyl) sulfinyl acetohydroxamic acid. Its molecular formula is C15H15NO3S. The drug's molecular weight is 289.4 daltons.

Adrafinil does not currently have FDA approval in the United States, although it is used in France and elsewhere in Europe. The drug is marketed by the American pharmaceutical company Cephalon, which acquired Group Lafon in 2001, under the brand name Olmifon.

History

Adrafinil was discovered in the late 1970s by scientists working with the French pharmaceutical company Group Lafon. The drug was first offered as an experimental treatment for narcolepsy in France in 1986. Later on, Lafon scientists developed modafinil as a stand-alone drug because the latter drug was understood to be a more highly selective alpha-1 adrenergic and also featured less in the way of side effects such as stomach pain, skin irritations, feelings of tension, and an increase in liver enzyme levels.

Trivia

The metabolites of Adrafinil contains sulfur, and can easily be detected by a peculiar odour of the urine of the person who has taken it.

References

See also

External links


fr:Adrafinil

This page uses Creative Commons Licensed content from Wikipedia (view authors).

Around Wikia's network

Random Wiki