Adenosine monophosphate

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style="background: #F8EABA; text-align: center;" colspan="2"	Adenosine monophosphate
Identifiers
SMILES	O[C@H]1[C@H]([C@@H]</br/>(O[C@@H]1COP(O)(O)=O)</br/>N2C3=C(N=C2)C(N)=NC=N3)O
Properties
Hazards
style="background: #F8EABA; text-align: center;" colspan="2"	Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

Adenosine monophosphate, also known as 5'-adenylic acid and abbreviated AMP, is a nucleotide that is found in RNA. It is an ester of phosphoric acid with the nucleoside adenosine. AMP consists of the phosphate group, the pentose sugar ribose, and the nucleobase adenine.

Contents 1 Production and degradation 2 cAMP 3 Application as a bitterness suppressor 4 See also 5 References 6 External links

[edit] Production and degradation

AMP can be produced during ATP synthesis by the enzyme adenylate kinase by combining two ADP molecules:

2 ADP → ATP + AMP

Or AMP may be produced by the hydrolysis of one high energy phosphate bond of ADP:

ADP → AMP + P_i

AMP can also be formed by hydrolysis of ATP into AMP and pyrophosphate:

ATP → AMP + PP_i

When RNA is broken down by living systems, nucleoside monophosphates, including adenosine monophosphate, are formed.

AMP can be regenerated to ATP as follows:

AMP + ATP → 2 ADP (adenylate kinase in the opposite direction)

2 ADP + 2 P_i → 2 ATP (this step is most often performed in aerobes by the ATP synthase during oxidative phosphorylation)

AMP can be converted into IMP by the enzyme myoadenylate deaminase, freeing an ammonia group.

In a catabolic pathway, adenosine monophosphate can be converted to uric acid, which is excreted from the body.

[edit] cAMP

AMP can also exist as a cyclic structure known as cyclic AMP (or cAMP). Within certain cells the enzyme adenylate cyclase makes cAMP from ATP, and typically this reaction is regulated by hormones such as adrenaline or glucagon. cAMP plays an important role in intracellular signaling.

[edit] Application as a bitterness suppressor

To human tastes, the bitterness suppressing quality of AMP interprets as food seeming 'sweeter'. This makes lower calorie food products more palatable, making AMP potentially a lucrative solution for food manufacturers as they respond to pressure from consumers and regulators concerned about social trends towards obesity.^[1] AMP has been approved by the Food and Drug Administration as a 'Bitter Blocker' additive to foodstuffs.^[2]

[edit] See also

• DNA
• Oligonucleotide

[edit] References

1. ↑ Nucleotide compounds that block the bitter taste of oral compositions patent by Linguagen Corp)
2. ↑ Bitter Blocker Backed

[edit] External links

• Computational Chemistry Wiki
• Blocking taste receptor activation of gustducin inhibits gustatory responses to bitter compounds
• Link page to external chemical sources.

This page uses content from the English-language version of Wikipedia. The original article was at Adenosine monophosphate. The list of authors can be seen in the page history. As with Psychology Wiki, the text of Wikipedia is available under the GNU Free Documentation License.