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An acetylcholinesterase inhibitor or anti-cholinesterase is a chemical that inhibits the cholinesterase enzyme from breaking down acetylcholine, so increasing both the level and duration of action of the neurotransmitter acetylcholine.
- occur naturally as venoms and poisons
- are used as weapons in the form of nerve agents
- are used medicinally:
- Phenanthrine derivatives
- donepezil, also known as E2020
- Tacrine, also known as tetrahydroaminoacridine (THA')
|Inhibitor||Duration||Main site of action||Clinical use||Adverse effects|
|edrophonium||short||neuromuscular junction||diagnosis of myasthenia gravis|
|physiostigmine||medium||postganglionic parasympathetic||treat glaucoma (eye drops)|
|dyflos||long||postganglionic parasympathetic||historically to treat glaucoma (eye drops)||toxic|
|ecothiopate||long||postganglionic parasympathetic||treat glaucoma (eye drops)||systemic effects|
Natural Compounds (Supplements)Edit
Some major effects of anticholinesterases:
- Actions on the autonomic nervous system, that is parasympathetic nervous system will cause bradycardia, hypotension, hypersecretion, bronchoconstriction, GI tract hypermotility, and decrease intraocular pressure.
- SLUD syndrome.
- Actions on the neuromuscular junction will result in prolonged muscle contraction.
See also Edit
- ↑ 1.0 1.1 1.2 1.3 Unless else specified n boxes, then ref is:Rang, H. P. (2003). Pharmacology, Edinburgh: Churchill Livingstone. Page 156
Anticholinesterases (N06DA, N07AA)
Psychoanaleptics: anti-dementia drugs (N06D)