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Ablative brain surgery

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Ablative brain surgery is the surgical ablation by burning or freezing of brain tissue to treat neurological or psychological disorders. The lesions it causes are irreversible.

Ablative brain surgery is also often used as an research tool in neurobiology. For example, by ablating specific brain regions and observing differences in animals subjected to behavioral tests, the functions of the removed areas may be inferred.


UsesEdit

Parkinson's diseaseEdit

Surgical ablation has been used to treat Parkinson's disease. In the 1990s, the pallidum was a common surgical target. Unilateral pallidotomy improves tremor and dyskinesia on one side of the body (opposite the side of the brain surgery), but bilateral pallidotomy was found to cause irreversible deterioration in speech and cognition. The thalamus is another potential target for treating tremor; in some countries, so is the subthalamic nucleus, although not in the United States due to its severe side effects. Generally, deep brain stimulation surgery (DBS) is considered preferable to ablation because it has the same effect and is adjustable and reversible.[1] However, for patients for whom DBS is not feasible, ablation of the subthalamic nucleus has been shown to be safe and effective.[2]

Cluster headachesEdit

Cluster headaches have been treated by ablation of the trigeminal nerve, but have not been very effective. Other surgical treatments for cluster headaches are under investigation.[3]

Psychiatric disordersEdit

In the People's Republic of China, surgical ablation was used to treat psychological and neurological disorders, particularly schizophrenia, but also including clinical depression, obsessive-compulsive disorder, and epilepsy.[4] The official Xinhua News Agency has since reported that China's Ministry of Health has banned the procedure for schizophrenia and severely restricted the practice for other conditions.[5]

MethodsEdit

Lasers have been shown to be effective in ablation of both cerebral and cerebellar tissue. A laser called Er:YAG, for example, allows great precision in location and size of the lesion and causes little to no thermal damage to adjacent tissue.[6]

ReferencesEdit

  1. Samii, Ali Stereotactic Surgery. American Parkinson Disease Association. URL accessed on 2008-05-01.
  2. O. Barlas, H. Hanagasi; M. Emre. Unilateral Ablative Lesions of the Subthalamic Nucleus in Advanced Parkinson Disease: Long-term Follow-up. (PDF) American Society for Stereotactic and Functional Neurosurgery. URL accessed on 2008-05-01.
  3. Stereotactic and Functional Neurosurgery News. (PDF) American Association of Neurological Surgeons. URL accessed on 2008-05-01.
  4. includeonly>Zamiska, Nicholas. "In China, Brain Surgery Is Pushed on the Mentally Ill", 'The Wall Street Journal', November 2, 2007. Retrieved on 2008-05-01.
  5. includeonly>Zamiska, Nicholas. "China Bans Irreversible Brain Procedure", 'The Wall Street Journal', April 28, 2008. Retrieved on 2008-05-01.
  6. Gülsoy, M., et al. (2001). Er:YAG Laser Ablation of Cerebellar and Cerebral Tissue. Lasers in Medical Science 16 (1).


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