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ADHD - Genetic factors

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The exact cause of ADHD remains unknown. Research suggests that ADHD arises from a combination of various genes, many of which affect dopamine transporters.[1]

Suspect genes include:

  • the 10-repeat allele of the DAT1 gene,[2]
  • the 7-repeat allele of the DRD4 gene,[2] and

Main article: ADHD - DRD4
  • the dopamine beta hydroxylase gene (DBH TaqI).[3]

See alsoEdit

References & BibliographyEdit

  1. Roman T, Rohde LA, Hutz MH. (2004). "Polymorphisms of the dopamine transporter gene: influence on response to methylphenidate in attention deficit-hyperactivity disorder." American Journal of Pharmacogenomics 4(2):83-92 PMID 15059031
  2. 2.0 2.1 Swanson JM, Flodman P, Kennedy J, et al. "Dopamine Genes and ADHD." Neurosci Biobehav Rev. 2000 Jan;24(1):21-5. PMID 10654656
  3. Smith KM, Daly M, Fischer M, et al. "Association of the dopamine beta hydroxylase gene with attention deficit hyperactivity disorder: genetic analysis of the Milwaukee longitudinal study." Am J Med Genet B Neuropsychiatr Genet. 2003 May 15;119(1):77-85. PMID 12707943

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