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Amiloride-sensitive cation channel 2, neuronal is a protein that in humans is encoded by the ACCN2 gene.[1][2]

Function Edit

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown. Alternative splicing of this gene generates 2 transcript products.[2]

Interactions Edit

ACCN2 has been shown to interact with PICK1.[3][4]

See also Edit

References Edit

  1. Garcia-Anoveros J, Derfler B, Neville-Golden J, Hyman BT, Corey DP (March 1997). BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. Proc Natl Acad Sci U S A 94 (4): 1459–64.
  2. 2.0 2.1 Entrez Gene: ACCN2 amiloride-sensitive cation channel 2, neuronal.
  3. Leonard, A Soren, Yermolaieva Olena, Hruska-Hageman Alesia, Askwith Candice C, Price Margaret P, Wemmie John A, Welsh Michael J (February 2003). cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1. Proc. Natl. Acad. Sci. U.S.A. 100 (4): 2029–34.
  4. Hruska-Hageman, Alesia M, Wemmie John A, Price Margaret P, Welsh Michael J (February 2002). Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel). Biochem. J. 361 (Pt 3): 443–50.

Further reading Edit

  • Corey DP, García-Añoveros J (1996). Mechanosensation and the DEG/ENaC ion channels. Science 273 (5273): 323–4.
  • Waldmann R (1997). A proton-gated cation channel involved in acid-sensing. Nature 386 (6621): 173–7.
  • Bassilana F (1997). The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties. J. Biol. Chem. 272 (46): 28819–22.
  • Bubien JK (1999). Malignant human gliomas express an amiloride-sensitive Na+ conductance. Am. J. Physiol. 276 (6 Pt 1): C1405–10.
  • Askwith CC (2000). Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels. Neuron 26 (1): 133–41.
  • Bässler EL (2001). Molecular and functional characterization of acid-sensing ion channel (ASIC) 1b. J. Biol. Chem. 276 (36): 33782–7.
  • Gunthorpe MJ, Smith GD, Davis JB, Randall AD (2001). Characterisation of a human acid-sensing ion channel (hASIC1a) endogenously expressed in HEK293 cells. Pflugers Arch. 442 (5): 668–74.
  • Duggan A, Garcia-Anoveros J, Corey DP (2002). The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons. J. Biol. Chem. 277 (7): 5203–8.
  • Ji HL (2002). Up-regulation of acid-gated Na(+) channels (ASICs) by cystic fibrosis transmembrane conductance regulator co-expression in Xenopus oocytes. J. Biol. Chem. 277 (10): 8395–405.
  • Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ (2002). Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel). Biochem. J. 361 (Pt 3): 443–50.
  • Wemmie JA (2002). The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory. Neuron 34 (3): 463–77.
  • Berdiev BK (2003). Protein kinase C isoform antagonism controls BNaC2 (ASIC1) function. J. Biol. Chem. 277 (48): 45734–40.
  • Ugawa S (2002). Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors. J. Clin. Invest. 110 (8): 1185–90.
  • Strausberg RL (2003). Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
  • Leonard AS (2003). cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1. Proc. Natl. Acad. Sci. U.S.A. 100 (4): 2029–34.
  • Wemmie JA (2004). Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior. Proc. Natl. Acad. Sci. U.S.A. 101 (10): 3621–6.
  • Poirot O, Vukicevic M, Boesch A, Kellenberger S (2004). Selective regulation of acid-sensing ion channel 1 by serine proteases. J. Biol. Chem. 279 (37): 38448–57.
  • Price MP (2005). Stomatin modulates gating of acid-sensing ion channels. J. Biol. Chem. 279 (51): 53886–91.


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