Wikia

Psychology Wiki

5-HT2 receptor

Talk0
34,139pages on
this wiki
Revision as of 17:42, February 11, 2008 by Dr Joe Kiff (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)

Assessment | Biopsychology | Comparative | Cognitive | Developmental | Language | Individual differences | Personality | Philosophy | Social |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |

Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)


The correct title of this article is 5-HT2 receptor. It appears incorrectly here because of technical restrictions.

5-HT2 receptors are a family of 5-HT receptors, with the following members:

Multiple receptor subtypes of serotonin (5-HT) neurotransmitters with multiple physiologic functions have been recognized. The 5-HT-2 receptors mediate many of the central and peripheral physiologic functions of serotonin. Cardiovascular effects include contraction of blood vessels and shape changes in platelets; central nervous system effects include neuronal sensitization to tactile stimuli and mediation of hallucinogenic effects of phenylisopropylamine hallucinogens. [1]

5-HT2A receptorsEdit

Main article: 5-HT2A receptor

This is the main excitatory receptor subtype among the GPCRs for serotonin (5-HT), although 5-HT2A may also have an inhibitory effect on certain areas such as the visual cortex and the orbitofrontal cortex. This receptor was given importance first as the target of psychedelic drugs like LSD. Later it came back to prominence because it was also found to be mediating, at least partly, the action of many antipsychotic drugs, especially the atypical ones.

5-HT2A also happens to be a necessary receptor for the spread of the human polyoma virus called JC virus.

Function Agonists Antagonists
  • CNS: neuronal excitation, behavioural effects, learning, anxiety
  • smooth muscle: contraction, vasoconstriction / vasodilatation
  • platelets: aggregation

5-HT2B receptorsEdit

Main article: 5-HT2B receptor
Function Agonists Antagonists

5-HT2C receptorsEdit

Main article: 5-HT2C receptor
Function Agonists Antagonists

ReferencesEdit

  1. [supplied by OMIM] Entrez Gene: HTR2B 5-hydroxytryptamine (serotonin) receptor 2B.



This page uses Creative Commons Licensed content from Wikipedia (view authors).

Around Wikia's network

Random Wiki